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Rich Diet Marks Messenger RNA Molecules for Breakdown in an Ancient Conserved Mechanism

Rich Diet Marks Messenger RNA Molecules for Breakdown in an Ancient Conserved Mechanism May 3, 2021 Share Caenorhabditis elegans, reveals. The findings of this collaborative study by scientists from the University of Geneva (UNIGE), Switzerland, and the Norwegian University of Science and Technology (NTNU) are published in an article titled, “Splice site m Cell. Methylation of RNA is essential. Earlier studies show without RNA methylation mice die at an early embryonic stage. In this study, the laboratories of Ramesh Pillai, PhD, and Florian Steiner, PhD, professors in the department of molecular biology at the UNIGE Faculty of Science, showed for the first time that methylation at the end of the intron of a particular gene (S-adenosylmethionine synthetase or SAM synthetase), blocks the splicing machinery the process that removes unnecessary noncoding sequences (introns) from the gene, leaving only the protein-coding sequences (exons) in a mature messenger RNA.

How diet controls RNA maturation

Date Time How diet controls RNA maturation Two UNIGE teams have discovered a new mechanism for regulating RNA maturation that depends on diet. The nematode C. elegans at two developmental stages: a larva and a developing embryo. © Joanna Wenda Particularly sensitive to chemical modifications, messenger RNAs (mRNAs) are molecules responsible for transmitting the information encoded in our genome, allowing for the synthesis of proteins, which are necessary for the functioning of our cells. Two teams from the University of Geneva (UNIGE), Switzerland, in collaboration with the Norwegian University of Science and Technology (NTNU), have focused on a specific type of chemical modification – called methylation – of mRNA molecules in the small worm Caenorhabditis elegans. They found that methylation on a particular sequence of an mRNA leads to its degradation and that this control mechanism depends on the worm’s diet. These findings are to be read in the journal Cell.

Miramar y sus tesoros gastronómicos

Miramar y sus tesoros gastronómicos
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