First cases of B.1.1.7 variant with E484K mutation in Pennsylvania

First cases of B.1.1.7 variant with E484K mutation in Pennsylvania
The B.1.1.7 variant was first detected in the United Kingdom last fall and has since spread globally. Now new reports are surfacing of the B.1.1.7 variant harboring the E484K mutation that is notorious for escaping neutralizing antibodies — including neutralizing activity from vaccine-induced immunity.
The E484K mutation has also been found on the B.1.351 and P.1 variant, contributing to their status as variants of concern. In February 2021, Public Health England published a report of 11 B.1.1.7 genomes that also had the E484K spike mutation. Currently, there are 247 isolates of B.1.1.7 + E484K reported globally, and new research finds the first reports of it in southeastern Pennsylvania.

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