Over the last 10 years, the international Decision Support Initiative (iDSI) has supported countries across Africa and Asia to develop national priority-setting processes. This month, in partnership with 15 iDSI authors, we have published a review of the successes, challenges, and lessons learned during these 10 years. This blog summarizes the six key messages of the paper from the perspective of CGD, the current secretariat of iDSI. We hope these six lessons inform success for the next 10 years of iDSI and serve as a useful guide for policy makers and their partners.