Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double-blind clinical controlled trial 1. Patients with type 2 diabetes randomized to using probiotic supplements were found to have significantly reduced lipoprotein-associated phospholipase A2 levels at 12-weeks follow-up. 2. Probiotic supplementation was also associated with improved glycemic control at follow-up.