The death was of a 77-year-old female.
On Wednesday the health department reported 47 new cases, which followed 71 new cases reported on Tuesday.
Laurel County has 1,320 active cases of the 3,190 total cases. Thirty-one of those active cases are hospitalized and 28 are in a congregate setting.
The Whitley County Health Department reported 38 new cases on Wednesday and 59 on Tuesday, bringing the county's total cases to 1,967. The active cases is reported as 390 with nine of those hospitalized.
Whitley County has seen 19 deaths related to the virus.
Knox County Health Department reported 25 new cases on Wednesday and 34 on Tuesday. The county has 1,624 total cases with 242 of those active.