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How does the structure of cytolysins influence their activity?


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IMAGE: First author and van der Donk lab member Imran Rahman (left) with Richard E. Heckert Professor of Chemistry Wilfred van der Donk.
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Credit: Jillian Nickel
Although Enterococcus faecalis is usually an innocuous member of the bacterial community in the human gut, it can also cause several infections, including liver disorders. The bacteria produce cytolysins, which are molecules that destroy cells. In a new study, researchers have uncovered how they do so.
Your chances of dying increase by 5-fold when you get infected by E. faecalis that can make cytolysin compared to those that cannot, said Wilfred van der Donk (MMG), a professor of chemistry and investigator of the Howard Hughes Medical Institute. Cytolysin is an important molecule and it has been known since the 1930s, our lab determined the cytolysin structure only in 2013. ....

Imran Rahman , Howard Hughes Medical Institute , Although Enterococcus , Howard Hughes Medical , Activity Relationships , Biology Interface Training , இம்ரான் ரஹ்மான் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ , நடவடிக்கை உறவுகள் ,