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New organelle involved in cancer metastasis discovered

New organelle involved in cancer metastasis discovered
10 Mar 2021
Some of Princeton s leading cancer researchers were startled to discover that what they thought was a straightforward investigation into how cancer spreads through the body - metastasis - turned up evidence of liquid-liquid phase separations: the new field of biology research that investigates how liquid blobs of living materials merge into each other, similar to the movements seen in a lava lamp or in liquid mercury.
We believe this is the first time that phase separation has been implicated in cancer metastasis, said Yibin Kang, the Warner-Lambert/Parke-Davis Professor of Molecular Biology. ....

Cliff Brangwynne , Lewis Thomas , Eric Wieschaus , Mark Esposito , Junek Wu , Ileana Cristea , Yibin Kang , Princeton University , Lewis Sigler Institute For Integrative Genomics , Princeton Bioengineering Initiative , Parke Davis Professor , Nature Cell , Biological Engineering , Squibb Professor , Molecular Biology , Lewis Sigler Institute , Casein Kinase , லெவிஸ் தாமஸ் , குறி எஸ்போசிட்டோ , ப்ரிந்ஸ்டந் பல்கலைக்கழகம் , லெவிஸ் சிகிலேர் நிறுவனம் க்கு ஒருங்கிணைந்த மரபியல் , ப்ரிந்ஸ்டந் உயிர் பொறியியல் முயற்சி , பார்க் டேவிஸ் ப்ரொஃபெஸர் , இயற்கை செல் , உயிரியல் பொறியியல் , ஸ்க்விப்ப் ப்ரொஃபெஸர் ,

Team discovers new organelle involved in cancer metastasis

Team discovers new organelle involved in cancer metastasis
March 10, 2021Princeton
Some of Princeton’s leading cancer researchers were startled to discover that what they thought was a straightforward investigation into how cancer spreads through the body metastasis turned up evidence of liquid-liquid phase separations: the new field of biology research that investigates how liquid blobs of living materials merge into each other, similar to the movements seen in a lava lamp or in liquid mercury.
“We believe this is the first time that phase separation has been implicated in cancer metastasis,” said Yibin Kang, the Warner-Lambert/Parke-Davis Professor of Molecular Biology. He is the senior author on a new paper featured on the cover of the current issue of Nature Cell Biology. ....

Cliff Brangwynne , Lewis Thomas , Eric Wieschaus , Mark Esposito , Ileana Cristea , Yibin Kang , Lewis Sigler Institute For Integrative Genomics , Princeton Bioengineering Initiative , Parke Davis Professor , Nature Cell , Biological Engineering , Squibb Professor , Molecular Biology , Lewis Sigler Institute , லெவிஸ் தாமஸ் , குறி எஸ்போசிட்டோ , லெவிஸ் சிகிலேர் நிறுவனம் க்கு ஒருங்கிணைந்த மரபியல் , ப்ரிந்ஸ்டந் உயிர் பொறியியல் முயற்சி , பார்க் டேவிஸ் ப்ரொஃபெஸர் , இயற்கை செல் , உயிரியல் பொறியியல் , ஸ்க்விப்ப் ப்ரொஃபெஸர் , மூலக்கூறு உயிரியல் , லெவிஸ் சிகிலேர் நிறுவனம் ,

Princeton team discovers new organelle involved in cancer metastasis

Princeton cancer researchers Mark Esposito and Yibin Kang discovered a new, still-unnamed organelle that plays a role in bone metastasis and is formed via liquid-liquid phase separation when liquid blobs of living materials merge into each other. “We believe this is the first time that phase separation has been implicated in cancer metastasis,” said Kang. ....

Cliff Brangwynne , Gary Laevsky , Mark Esposito , Junek Wu , Ileana Cristea , Yibin Kang , Lewis Thomas , Eric Wieschaus , Lewis Sigler Institute For Integrative Genomics , Princeton Bioengineering Initiative , Parke Davis Professor , Nature Cell , Biological Engineering , Squibb Professor , Molecular Biology , Lewis Sigler Institute , குறி எஸ்போசிட்டோ , லெவிஸ் தாமஸ் , லெவிஸ் சிகிலேர் நிறுவனம் க்கு ஒருங்கிணைந்த மரபியல் , ப்ரிந்ஸ்டந் உயிர் பொறியியல் முயற்சி , பார்க் டேவிஸ் ப்ரொஃபெஸர் , இயற்கை செல் , உயிரியல் பொறியியல் , ஸ்க்விப்ப் ப்ரொஃபெஸர் , மூலக்கூறு உயிரியல் , லெவிஸ் சிகிலேர் நிறுவனம் ,

American scientists receive the 2021 Paul Ehrlich and Ludwig Darmstaedter Prize

American scientists receive the 2021 Paul Ehrlich and Ludwig Darmstaedter Prize
FRANKFURT am MAIN. Two American scientists, Bonnie L. Bassler and Michael R. Silverman, receive the 2021 Paul Ehrlich and Ludwig Darmstaedter Prize, which is endowed with 120,000 €.
Bassler is Professor at Princeton University and a Howard Hughes Medical Institute Investigator, Michael R. Silverman is Emeritus Professor of the Agouron Institute in La Jolla.
The two researchers are honoured for their ground-breaking discoveries concerning bacterial quorum sensing , which refers to sophisticated systems of cell-to-cell communication that bacteria use to coordinate group behaviors.
The award ceremony in St. Paul s Church, which is traditionally held on March 14, Paul Ehrlich s birthday, has been postponed due to the Coronavirus pandemic. Instead, Bassler and Silverman will receive the award at the ceremony in 2022. ....

United States , Ludwig Darmstaedter , Katja Becker , Janssen Cilag Gmb , Thomas Boehm , Emily Henderson , Wolfgang Schleussner Stiftung , Sanofi Aventis Deutschland Gmb , Wilhelm Bender , Michaelr Silverman , Bonniel Bassler , Jochen Maas , Michael Silverman , Paul Ehrlich , Bonnie Bassler , Hedwig Ehrlich , Joanne Engebrecht , Royal Society , Board Of Trustees , Head Of Research , Max Planck Institute For Immunobiology , United States National Science Board , Paul Ehrlich Foundation , Merck Kga , Board Of Trustees Is Professor Dr , La Roche Ltd ,