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Signal detection theory can be used to better understand cognitive fatigue A team of New Jersey researchers has shown that changes in perceptual certainty and response bias, two central metrics of signal detection theory (SDT), correlate with changes in cognitive fatigue. They also show that SDT measures change as a function of changes in brain activation. This finding was reported in Frontiers in Psychology on January 15, 2021, in the open access article Using Signal Detection Theory to Better Understand Cognitive Fatigue (doi:10.3389/fpsyg.2020.579188). The authors are Glenn Wylie, DPhil, Brian Yao, PhD, and John DeLuca, PhD, of Kessler Foundation, and Joshua Sandry, PhD, of Montclair State University. ....
(0) NEW YORK, NY / ACCESSWIRE / April 1, 2021 / Kadmon Holdings, Inc. (NASDAQ:KDMN) today announced that the first patient has been dosed in an open-label Phase 2 clinical trial of belumosudil, the Company s ROCK2 inhibitor, in patients with diffuse cutaneous systemic sclerosis (dcSSc), a chronic immune disorder characterized by fibrosis of the skin and internal organs. The Phase 2 study (KD025-215) will enroll up to 15 adults with dcSSc who will receive orally administered belumosudil 200 mg twice daily (BID). The primary endpoint is the Combined Response Index for Systemic Sclerosis (CRISS) score. The Company plans to present initial data from this study by year-end 2021. In addition to the KD025-215 trial, an ongoing, double-blind, placebo-controlled Phase 2 clinical trial of belumosudil (KD025-209) is currently enrolling 60 adults with dcSSc. Patients are randomized to receive belumosudil 200 mg once daily (QD), belumosudil 200 mg BID or placebo. ....