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Frontiers | Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction



1Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States
2Molecular and Cellular Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, United States
3Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States
4Center for Translational Medicine, Temple University, Philadelphia, PA, United States
Background: Endothelial cells (ECs) play a critical role in the maintenance of vascular homeostasis and in heart function. It was shown that activated fibroblast-derived exosomes impair cardiomyocyte function in hypertrophic heart, but their effect on ECs is not yet clear. Thus, we hypothesized that activated cardiac fibroblast-derived exosomes (FB-Exo) mediate EC dysfunction, and therefore modulation of FB-exosomal contents may improve endothelial function. ....

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Adelaide United player speaks out after racial abuse, as Crows back push for 'sport-wide' bans


Adelaide United player speaks out after racial abuse, as Crows back push for sport-wide bans
TueTuesday 16
Kusini Yengi was racially targeted after his match-winning performance.
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Adelaide United s Kusini Yengi has expressed support for his club s push to have racial abusers banned from all elite sporting events, after the young star was vilified following his performance against Melbourne Victory.
Key points:
After the game, he was racially abused in comments on his Instagram account
He has vowed to continue celebrating goals with gusto
Yengi provided the spark off the bench as the Reds came from behind to win 3-1 on Saturday, scoring one goal and setting up another to seal the win. ....

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