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Am I at risk? Non-alcoholic fatty liver disease is caused by a build-up of fat in your liver. No one is certain why this happens. Many doctors believe that it’s linked to the way your body responds to the hormone insulin – this is called insulin resistance, says Bupa. According to the health body, you may be more at risk of getting non-alcoholic fatty liver disease if: You’re overweight, especially if you carry extra weight around your middle You have type 2 diabetes You have high blood pressure (hypertension) You have high levels of fats in your bloodstream – known as hyperlipidaemia ....