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31 March 2021 The liver is one of the organs most susceptible to drug toxicity and drug induced liver injury (DILI). DILI is a major cause of drug attrition, with more than 750 FDA approved drugs known to have a degree of DILI risk. There are a number of strategies to de-risk DILI in drug discovery and, in recent years, focus has turned to human in vitro 3D liver models to better predict DILI in early and pre-clinical development. These models culture primary human liver cells, often in co-cultures, in a physiologically relevant environment allowing them to stay functional for extended periods of time. This application assesses whether a microphysiological system (MPS), also known as Organ-on-a-Chip (OOC), in vitro liver model could be used to understand the detailed mechanistic aspects of liver toxicity. ....
26 February 2021 Twenty-seven GC-amenable pesticides and their isomers regulated in the cannabis industry in North America stand out as challenging to analyze using liquid chromatography-triple quadrupole mass spectrometry (TQ LC/MS) with electrospray ionization (ESI). In this application note, Agilent Technologies outlines a complete workflow that achieves required limits of detection (LOD), limits of quantitation (LOQ), accuracy, and precision defined by the California Bureau of Cannabis Control (BCC) and Health Canada in dry cannabis flower. Download 10,000+ ....
16 February 2021 Elemental analysis with traditional EDS (energy dispersive X-ray spectroscopy) runs on a dedicated hardware and software system. This requires constant switching between two separate operating platforms, usually navigating through complex workflows to get to the answer. In this application note, discover how the Thermo Scientific™ ColorSEM™ Technology can overcome this, delivering new levels of speed, convenience, and insight during SEM EDS analysis. Download it below to learn more about: The X-rays collection process Download 10,000+ ....