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Starving cancer cells of the energy they need to grow could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, according to a new study. Studying human cancer cells and mice, researchers report that a two-drug combination targeting a tumor’s energy sources could prove as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer. Osteosarcoma is the most common tumor of the bone in adults and children. It accounts for about 4% of all pediatric cancers and more than half of all pediatric bone cancers. Standard treatment for osteosarcoma includes surgery, radiation, and a cocktail of chemotherapy drugs including high-dose methotrexate, which can cause liver and kidney damage. ....
Two drugs targeting cancer cells’ energy source potentially could replace toxic chemo in osteosarcoma January 26, 2021 SHARE A new study from Washington University School of Medicine in St. Louis suggests that a two-drug combination targeting a tumor’s energy sources could be as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer. Shown is a cross section of osteosarcoma. (Image: Richa Rathore) An innovative approach to treating bone tumors starving cancer cells of the energy they need to grow could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. Studying human cancer cells and mice, the researchers said that a two-drug combination targeting a tumor’s energy sources could be as effective and less toxic than methotrexate, a l ....
E-Mail IMAGE: A new study from Washington University School of Medicine in St. Louis suggests that a two-drug combination targeting a tumor s energy sources could be as effective and less toxic than. view more Credit: RICHA RATHORE An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. Studying human cancer cells and mice, the researchers said that a two-drug combination targeting a tumor s energy sources could be as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer. ....