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Gift boosts efforts to understand and combat rare cancers


Gift boosts efforts to understand and combat rare cancers
Apr 9 2021
Curing cancer has been the dream of countless doctors and researchers over the decades. Yet some types of cancer, whether because they affect relatively few people or lack influential advocates, receive less attention and funding than others.
Cells from a rare cancer known as blastic plasmacytoid dendritic cell neoplasm, shown in purple and blue, appear among red blood cells. Image: Clin Med Insights Case Rep 2013. doi: 10.4137/CCRep.S12608, CC-BY-NC 3.0
A recent gift to Harvard Medical School is boosting efforts to understand and combat these understudied malignancies.
Established at HMS in 2019 by the Switzerland-based Bertarelli Foundation, the Bertarelli Rare Cancers Fund provides $15 million in support of research projects and community building around rare cancers. ....

United States , Dana Farber Cancer Institute , Dona Bertarelli , Kimberly Stegmaier , Austinl Vickery Jr , Stephen Elledge , Nabeel Bardeesy , Georgeq Daley , Fred Harlow , Vamsi Mootha , John Hanna , William Kaelin , John Iafrate , Miguel Rivera , National Cancer Institute , Harvard Medical School , Bertarelli Rare Cancers Fund , Bertarelli Foundation , Dk Ludwig Professor Of Cancer Research , Bertarelli Program In Translational Neuroscience , Blavatnik Institute , Clin Med Insights Case Rep , Switzerland Based Bertarelli Foundation , National Cancer , Cancer Research , Sidney Farber Professor ,

SARS-CoV-2 hijacks two key metabolic pathways to rapidly replicate in host cells


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When SARS-CoV-2, the virus that causes COVID-19, infects a human cell, it quickly begins to replicate by seizing the cell s existing metabolic machinery. The infected cells churn out thousands of viral genomes and proteins while halting the production of their own resources. Researchers from Brigham and Women s Hospital, Massachusetts General Hospital (MGH), and the Broad Institute, studying cultured cells shortly after infecting them with the virus, now have more insight into the metabolic pathways co-opted by the virus. The findings, published in
Nature Communications, highlight the potential therapeutic benefit of drugs such as methotrexate, which inhibit folate and one-carbon metabolic pathways appropriated by the virus. ....

United States , Vamsi Mootha , Benjamin Gewurz , Broad Institute , Burroughs Wellcome Career Award In Medical Sciences , Nature Communications , National Institutes Of Health , Division Of Infectious Diseases , Howard Hughes Medical Institute , Massachusetts General Hospital , National Institutes , Burroughs Wellcome Career Award , Medical Sciences , Medicine Health , Infectious Emerging Diseases , ஒன்றுபட்டது மாநிலங்களில் , வம்சி மூத்தா , பரந்த நிறுவனம் , பரோக்கள் வெல்கம் தொழில் விருது இல் மருத்துவ அறிவியல் , இயற்கை தகவல்தொடர்புகள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , பிரிவு ஆஃப் தொற்று நோய்கள் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , தேசிய நிறுவனங்கள் , பரோக்கள் வெல்கம் தொழில் விருது ,

Isha Jain Joins Gladstone Institutes


Isha Jain Joins Gladstone Institutes
A scientist since childhood, Jain will now lead a lab at Gladstone to study the balance of oxygen levels in the human body
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SAN FRANCISCO, Dec. 16, 2020 /PRNewswire/ Oxygen is vital for all life, but in the human body, the level of oxygen must be just right. Too much or too little oxygen can contribute to the damage caused by a variety of medical conditions, from heart attacks, to cancer, to neurodegenerative diseases.
Understanding the precise balance of oxygen levels in biological processes and how to fine-tune them to potentially treat disease is the main research focus of Isha Jain, PhD, who is joining Gladstone Institutes as an assistant investigator. ....

Lehigh University , United States , Mission Bay , San Francisco , Warren Zapol , Vamsi Mootha , Erin Oshea , Benoit Bruneau , Kathy Iovine , Deepak Srivastava , Disha Jain , Gladstone Institute Of Cardiovascular Disease , Harvard University , Sandler Fellows Program , Gladstone Institute , Erino Shea , Goldilocks Principle , Bay Area , Gladstone Institutes , Julie Langelier , Assistant Director , லேஹி பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , பணி வளைகுடா , சான் பிரான்சிஸ்கோ , வம்சி மூத்தா ,