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by Mark Derewicz February 2, 2021 . CHAPEL HILL – Many molecules in our bodies help our immune system keep us healthy without overreacting so much that our immune cells cause problems, such as autoimmune diseases. One molecule, called AIM2, is part of our innate immunity – a defense system established since birth – to fight pathogens and keep us healthy. But little was known about AIM2’s contribution to T cell adaptive immunity – defenses developed in response to particular pathogens and health problems we develop over the course of our lives. Now, UNC School of Medicine scientists co-led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealou ....
E-Mail CHAPEL HILL, NC - Many molecules in our bodies help our immune system keep us healthy without overreacting so much that our immune cells cause problems, such as autoimmune diseases. One molecule, called AIM2, is part of our innate immunity - a defense system established since birth - to fight pathogens and keep us healthy. But little was known about AIM2 s contribution to T cell adaptive immunity - defenses developed in response to particular pathogens and health problems we develop over the course of our lives. Now, UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that o ....