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Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses


Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses
The search for effective inhibitors with therapeutic potential against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the shattering pandemic of coronavirus disease 2019 (COVID-19), has thrown up some surprising results.
A new study, released as a preprint on the
bioRxiv server, deals with the inhibitory activity of a membrane protein that has broad-spectrum activity against multiple viruses, showing that this is due to its effect on cytoplasmic lysine residue incorporation into replicating virions.
MARCH8 inhibits envelope protein expression
The membrane-associated RING-CH (MARCH) 8 protein is one of eleven similar proteins that form one category of RING-finger E3 ubiquitin ligases. It has two transmembrane domains linked by a short ectodomain. It reduces the expression of many host transmembrane proteins, such as the stra ....

Liji Thomas , Cross River , Coronavirus Disease Covid 19 , Ars Cov 2 , Hiv 1 , Protein Expression , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Ubiquitin Ligase , ரோஸ் நதி ,

Chilling forecast of when Cairns could run out of water


Environment
by Bronwyn Farr
Premium Content
Subscriber only
CAIRNS could face dire water restrictions by 2027 as the region s growth outstrips supply - and Cairns Regional Council is after a big-ticket item in the federal budget to remedy a looming crisis.
The council wants $215m for its Cairns Water Security Stage 1 project which will involve water infrastructure on the Mulgrave River to deliver water into the main network, saying Copperlode Dam and Behana Creek will fail to meet future needs.
Cairns Mayor Bob Manning says federal funding for Mulgrave River water infrastructure is essential for the region’s future. Picture: Brendan Radke ....

Cross River , Mount Peter , South Australia , Mulgrave River , Bryce Chapman , Bob Manning , Brendan Radke , Cairns Regional Council , Cairns Performing Arts Centre , Cairns Water Security Stage , Copperlode Dam , Behana Creek , Mayor Bob Manning , River Dam , Infrastructure Australia , Munro Martin Parklands , Federal Budget , Water Restrictions , ரோஸ் நதி , ஏற்ற பீட்டர் , தெற்கு ஆஸ்திரேலியா , முல்‌க்ரேவ் நதி , பரிஸ் சாப்மேன் , பாப் மானிங் , பிரெண்டன் றாட்கே , கெய்ர்ன்ஸ் பிராந்திய சபை ,

Australian mRNA vaccines?


Australian mRNA vaccines?
Credit: franckreporter / istock / Getty Images
Yesterday the Victorian Government announced a $50 million investment to set up a facility to develop and manufacture mRNA vaccines in Australia. Monash University’s experts will work with the Victorian Government, the University of Melbourne and The Doherty Institute to establish and scale mRNA vaccine manufacturing.
“That’s just the start,” says Associate Professor Archa Fox, a molecular biologist and mRNA expert at the University of Western Australia.
Although it’s early days, the Victorian Government announcement has been welcomed with enthusiasm by the Australian scientific community.
“Great development… It’s time for all States and Territories to engage – we need to go further and establish a federated, collaborative and flexible network of R&D/manufacturing/clinical trials capability and capacity,” tweeted Professor Paul Young, a molecular virologist and research ....

South Australia , Cross River , Papua New Guinea , Paul Young , Marcha Fox , Colin Pouton , Monash University , University Of Melbourne , Doherty Institute , University Of Queensland , University Of Western Australia , Victorian Government , Associate Professor Archa Fox , Professor Paul Young , Professor Colin Pouton , Professor Peter Doherty , South Pacific , தெற்கு ஆஸ்திரேலியா , ரோஸ் நதி , பப்புவா புதியது கினியா , பால் இளம் , அர்ச்சா நரி , மோனாஷ் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் மெல்போர்ன் , டோவர்டீ நிறுவனம் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து ,