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Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses The search for effective inhibitors with therapeutic potential against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the shattering pandemic of coronavirus disease 2019 (COVID-19), has thrown up some surprising results. A new study, released as a preprint on the bioRxiv server, deals with the inhibitory activity of a membrane protein that has broad-spectrum activity against multiple viruses, showing that this is due to its effect on cytoplasmic lysine residue incorporation into replicating virions. MARCH8 inhibits envelope protein expression The membrane-associated RING-CH (MARCH) 8 protein is one of eleven similar proteins that form one category of RING-finger E3 ubiquitin ligases. It has two transmembrane domains linked by a short ectodomain. It reduces the expression of many host transmembrane proteins, such as the stra ....
Environment by Bronwyn Farr Premium Content Subscriber only CAIRNS could face dire water restrictions by 2027 as the region s growth outstrips supply - and Cairns Regional Council is after a big-ticket item in the federal budget to remedy a looming crisis. The council wants $215m for its Cairns Water Security Stage 1 project which will involve water infrastructure on the Mulgrave River to deliver water into the main network, saying Copperlode Dam and Behana Creek will fail to meet future needs. Cairns Mayor Bob Manning says federal funding for Mulgrave River water infrastructure is essential for the region’s future. Picture: Brendan Radke ....
Chilling forecast of when Cairns could run out of water cqnews.com.au - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from cqnews.com.au Daily Mail and Mail on Sunday newspapers.
Australian mRNA vaccines? Credit: franckreporter / istock / Getty Images Yesterday the Victorian Government announced a $50 million investment to set up a facility to develop and manufacture mRNA vaccines in Australia. Monash University’s experts will work with the Victorian Government, the University of Melbourne and The Doherty Institute to establish and scale mRNA vaccine manufacturing. “That’s just the start,” says Associate Professor Archa Fox, a molecular biologist and mRNA expert at the University of Western Australia. Although it’s early days, the Victorian Government announcement has been welcomed with enthusiasm by the Australian scientific community. “Great development… It’s time for all States and Territories to engage – we need to go further and establish a federated, collaborative and flexible network of R&D/manufacturing/clinical trials capability and capacity,” tweeted Professor Paul Young, a molecular virologist and research ....
Rain City Resources Inc. Options Bro Property and Amends Financing streetinsider.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from streetinsider.com Daily Mail and Mail on Sunday newspapers.