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Study shows cerium-134 could help advance targeted cancer treatment


Study shows cerium-134 could help advance targeted cancer treatment
Marilyn Sargent/Berkeley Lab/Courtesy
Katherine Shield (from left), Dahlia An, Tyler Bailey at Lawrence Berkeley National Laboratory on Tuesday, Nov. 17 in Berkeley, California.
Researchers in Rebecca Abergel s lab have developed cerium-134, a radioisotope that could be used as an imaging agent for a promising form of cancer treatment known as targeted alpha therapy.
In a recently published study, researchers identified ways to produce and purify cerium-134, a radioisotope that could help advance forms of cancer treatment.
As a collaborative effort, the study was conducted by the Lawrence Berkeley National Laboratory, the Los Alamos National Laboratory and UC Berkeley. Researchers from the labs have found a way to use cerium-134 as an imaging agent for a promising form of cancer treatment known as targeted alpha therapy, or TAT. ....

Stosh Kozimor , Rebecca Abergel , Lawrence Berkeley National Laboratory , Los Alamos National Laboratory , ரிபேக்க அபேர்கெல் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் , லாஸ் அலமோஸ் தேசிய ஆய்வகம் ,

Scientists recruit new atomic heavyweights in targeted fight against cancer


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IMAGE: Katherine Shield (from left), Dahlia An, Tyler Bailey at Lawrence Berkeley National Laboratory on Tuesday, November 17, 2020, in Berkeley, Calif.
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Credit: Marilyn Sargent/Berkeley Lab
A promising approach to treating cancer - called targeted alpha-particle therapy or TAT - could better harness the curative power of radiation treatments and lessen the severity of their more debilitating side effects.
TAT recruits drugs containing radioactive materials called alpha-emitting radioisotopes or radionuclides combined with cell-targeting molecules like antibodies. As alpha-emitting radioisotopes decay, they emit radiation in the form of highly energetic particles called alpha particles. Cell-targeting antibodies guide these alpha-emitting radioisotopes, like super-tiny guided missiles, to their final destination: cancer cells. ....

United States , Los Alamos , Kellen Obrien , Stosh Kozimor , Michael Fassbender , Meiring Nortier , Rebecca Abergel , Eva Birnbaum , Jim Oneil , Tyler Bailey , Frankie White , Veronika Mocko , Andrew Lakes , Etienne Vermeulen , Stacey Gauny , Sara Thiemann , Jonathan Engle , Lee Bernstein , Jason Cooley , Mark Brugh , University Of California , Los Alamos Neutron Science Center , Los Alamos National Laboratory , Office Of Science , Berkeley Lab Molecular Biophysics , National Accelerator Laboratory ,