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Researchers Identify Inflamed Brain Cells Likely Involved in MS Nerve Degeneration

Researchers Identify Inflamed Brain Cells Likely Involved in MS Nerve Degeneration
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Daniel Reich , Johns Hopkins , Martina Absinta , Peter Calabresi , Johns Hopkins Multiple Sclerosis Precision Medicine Center , Conradn Hilton Foundation , Cariplo Foundation , Intramural Research Program , Adelson Medical Research Foundation , National Institute Of Neurological Disorders , Johns Hopkins Medicine , National Institute , Neurological Disorders , National Institutes , Translational Neuroradiology Section , டேனியல் ரீச் , ஜான்ஸ் ஹாப்கின்ஸ் , பீட்டர் சலபிரேசி , அகச்சிதைவு ஆராய்ச்சி ப்ரோக்ர்யாம் , தேசிய நிறுவனம் ஆஃப் நரம்பியல் கோளாறுகள் , ஜான்ஸ் ஹாப்கின்ஸ் மருந்து , தேசிய நிறுவனம் , நரம்பியல் கோளாறுகள் , தேசிய நிறுவனங்கள் , மொழிபெயர்ப்பு நரம்பியல் பிரிவு ,

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study
Vijay R. Varma ,
Roles
Conceptualization,
Data curation,
Formal analysis,
Investigation,
Methodology,
Project administration,
Supervision,
Visualization,
Writing – original draft,
Writing – review & editing
¶‡ These authors share first authorship on this work.
Affiliation
Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America
¶‡ These authors share first authorship on this work.
Affiliation
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yang An, ....

United Kingdom , Lilliana Posey , Carol Brayne , National Cancer Institute , National Institute On , University Of Cambridge , Clinical Practice Research Datalink , Alzheimer Disease Metabolomics Consortium , Hepatocyte Nuclear Factor , Groupa Member , Laboratory Of Behavioral Neuroscience , Grouph Member , Alzheimer Disease Neuroimaging Initiative , Alzheimer Disease Neuroimaging Network , Groupi Member , Consortium Molecular Mechanisms Of The Vascular Etiology , Medicines Partnership , Groupc Member , Nuclear Receptor , Scientific Advisory Committee , National Institute On Aging , Baltimore Longitudinal Study , Disease Neuroimaging Initiative , Religious Orders Study , Aging Project , Creative Commons ,

Changes in how cholesterol breaks down in the body may accelerate progression of dementia

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IMAGE: Investigators with the National Institute on Aging, part of the National Institutes of Health, are searching for drug candidates that may correct the brain s metabolic abnormalities, such as cholesterol breakdown.
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Credit: Dr. Vijay R. Varma
The blood-brain barrier is impermeable to cholesterol, yet high blood cholesterol is associated with increased risk of Alzheimer s disease and vascular dementia. However, the underlying mechanisms mediating this relationship are poorly understood. A study published in the open-access journal
PLOS Medicine by Vijay Varma and colleagues at the National Institute on Aging, part of the National Institutes of Health, in Baltimore, Maryland, suggests that disturbances in the conversion of cholesterol to bile acids (called cholesterol catabolism) may play a role in the development of dementia. ....

National Institutes Of Health , United States , United Kingdom , Lilliana Posey , Madhav Thambisetty , Vijay Varma , National Cancer Institute , Alzheimer Disease Neuroimaging Initiative , Consortium Molecular Mechanisms Of The Vascular Etiology , National Institute On , Research Article , Medicines Partnership , Laboratory Of Behavioral Neuroscience , National Institute On Aging , National Institute , National Institutes , Baltimore Longitudinal Study , Disease Neuroimaging Initiative , Translational Neuroscience , Drug Repurposing , Effective Alzheimer , Accelerated Medicines Partnership , Target Discovery , Preclinical Validation Project , Molecular Mechanisms , Vascular Etiology ,