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A new 3D model for myotonic dystrophy Myotonic dystrophy is a hereditary degenerative neuromuscular disease that occurs mainly in adults, affecting about 50,000 people only in Spain. Symptoms range from difficulty walking and myotonia (great difficulty in relaxing the contracted muscles) to severe neurological problems, leading to progressive disability that unfortunately puts many of those affected in a wheelchair. This disease is very heterogeneous among patients (age of onset, progression, hereditary transmission, affected muscles), which makes the development of generic treatments especially complex. Currently, drugs against myotonic dystrophy are developed in animal models such as Drosophila, the fruit fly, or in 2D cell cultures. They are later tested in mice and finally in patients. Unfortunately using these approaches, some of the drugs that have been developed have not been able to reach the last stages of clinical trials because they were not effective i ....
Advocates for people with disabilities are fighting for stronger communication and vaccine availability from a state level. Author: Chris Latella Updated: 7:19 PM MST March 4, 2021 ARIZONA, USA Advocates for those with disabilities expressed their concern and frustration Thursday about the vaccine distribution phases. They say their attempts to get the Governor’s Office to recognize the disabled community as a high-need group, have gone unanswered. For many of those with disabilities, who do not live in nursing or care homes, the wait to get a vaccine is a matter of life and death. Louis Hopkins suffers from Myotonic Dystrophy, a genetic disorder that causes progressive muscle weakness, including in respiratory muscles. Hopkins relies on a constant stream of oxygen to survive. ....