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Cantargia advance development of antibody CAN04 by a new clinical trial in triple negative breast cancer


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STOCKHOLM, May 6, 2021 /PRNewswire/
Cantargia AB today announced signing a Letter of Intent with the Spanish Breast Cancer Group (GEICAM) to perform a new clinical trial investigating the antibody nadunolimab (CAN04) in combination with carboplatin/gemcitabine for the treatment of patients with advanced triple negative breast cancer (TNBC). The trial will investigate the safety and efficacy of the combination in this difficult to treat breast cancer. The total number of patients is estimated to be up to 120 and includes a randomized part after initial safety lead in. The protocol is planned to be submitted during Q2 2021.
Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP). The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Cytotoxicity (ADCC). Preclinical data show that CAN04 can increase the efficacy of chemotherapy. CA ....

Miguel Mart , Spanish Breast Cancer Group , Antibody Dependent Cellular Cytotoxicity , Nasdaq Stockholm , மிகுவல் மார்ட் , நாஸ்டாக் ஸ்டாக்‌ஹோல்ம் ,

Guatemala: Free Press Under Attack - Guatemala


Guatemala: Free Press Under Attack
Format
Harassment, Limited Access to Information, Poor Investigations of Attacks
(New York) – The administration of President Alejandro Giammattei in Guatemala has targeted the media through bellicose rhetoric and false accusations throughout the president’s first year in office, Human Rights Watch and the Committee to Protect Journalists (CPJ) said today. Investigations into threats, attacks, and two killings of journalists during this period have made little progress.
The government’s verbal attacks against journalists became more frequent and prominent after Covid-19 began to spread in Guatemala in March 2020, and the authorities have restricted access to information about the pandemic. The administration has also failed to ensure that investigators and prosecutors have the necessary resources to conduct prompt and effective investigations into attacks against journalists. The government should urgently stop harassing ind ....

New York , United States , Guatemala City , San Marcos , Natalie Southwick , Miguel Mart , Francis Masek , Carlos Sandoval , Carlos Sebasti , Edwin Asturias , Amelia Flores , Jovanna Garc , Miguel Vivanco , Alejandro Giammattei , Sonny Figueroa , Bryan Guerra , Health Ministry Whatsapp , International Safe Abortion Day , Prosecutor Office For Crimes Against Journalists , Prosecutor Office , Ombudsperson Office , National Office For Access To Public Information , Guatemalan Army , Prosecutor Office For Crimes , Presidential Commission For Attention , Access To Information Including On Covid ,

Guatemala: Free Press Under Attack


Harassment, Limited Access to Information, Poor Investigations of Attacks
Guatemala s President Alejandro Giammattei gives a press conference at the National Theatre, the day before his inauguration in Guatemala City, on Jan. 13, 2020.
© 2020 AP Photo/Moises Castillo
(New York) – The administration of President Alejandro Giammattei in Guatemala has targeted the media through bellicose rhetoric and false accusations throughout the president’s first year in office, Human Rights Watch and the Committee to Protect Journalists (CPJ) said today. Investigations into threats, attacks, and two killings of journalists during this period have made little progress.
The government’s verbal attacks against journalists became more frequent and prominent after Covid-19 began to spread in Guatemala in March 2020, and the authorities have restricted access to information about the pandemic. The administration has also failed to ensure that ....

New York , United States , Guatemala City , San Marcos , Natalie Southwick , Miguel Mart , Francis Masek , Carlos Sandoval , Carlos Sebasti , Edwin Asturias , Amelia Flores , Jovanna Garc , Miguel Vivanco , Alejandro Giammattei , Sonny Figueroa , Bryan Guerra , Health Ministry Whatsapp , International Safe Abortion Day , Prosecutor Office For Crimes Against Journalists , Prosecutor Office , Ombudsperson Office , National Office For Access To Public Information , Guatemalan Army , Prosecutor Office For Crimes , Presidential Commission For Attention , Access To Information Including On Covid ,