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How to Know If You're Maximizing Your mAb Recovery


How to Know If You re Maximizing Your mAb Recovery
High concentration mAb formulations and their properties
Image credit: Pall Corporation
Having first emerged as therapeutics in the 1980s, monoclonal antibodies (mAbs) are the predominant class of recombinant biologic drugs in development.
While intravenous (IV) infusion is a frequently utilized administration route for mAbs, for patients requiring a frequent dosing regimen, subcutaneous delivery (sub-C) in doses between 1-1.5 mL is now preferred as it supplies the possibility of self-treatment by utilizing pre-filled syringes
2.
mAbs are usually required to be prepared at concentrations that are higher than 100 g/L and up to 250 g/L ....

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Vir Biotechnology and GSK Announce VIR-7831 Reduces Hospitalization and Risk of Death in Early Treatment of Adults with COVID-19


Vir Biotechnology and GSK Announce VIR-7831 Reduces Hospitalization and Risk of Death in Early Treatment of Adults with COVID-19
March 10, 2021 20:22 ET
| Source:
Vir Biotechnology, Inc.
Vir Biotechnology, Inc.
San Francisco, California, UNITED STATES
– Independent Data Monitoring Committee recommends stopping Phase 3 COMET-ICE trial early given an 85% reduction in hospitalization or death –
– Vir and GSK plan to immediately seek Emergency Use Authorization in the U.S. and authorizations in other countries –
– Additional new in vitro studies indicate VIR-7831 maintains activity against major circulating COVID-19 variants –
SAN FRANCISCO and LONDON, March 10, 2021 (GLOBE NEWSWIRE) Vir Biotechnology, Inc. (Nasdaq: VIR) and GlaxoSmithKline plc (LSE/NYSE: GSK) today announced that an Independent Data Monitoring Committee (IDMC) recommended that the Phase 3 COMET-ICE (COVID-19 Monoclonal ....

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Mitchells & Butlers sales plunge 70% as lockdowns bite | 22 February 2021


22 February 2021 | 07:08am
StockMarketWire.com - Pub group Mitchells & Butlers, while launching a planned £350 million equity raising, said its sales had fallen sharply due to the UK s Covid-19 lockdown.
Managed sales between 27 September and 16 January had dropped 70% year-on-year, the company said.
On a like-for-like basis for sites when open, excluding periods of closure trading was down 30%.
Mitchells & Butlers said none of its sites had been open since the government announced fresh lockdown measures on 30 December.
The company had a cash balance of £113 million at 16 January with all facilities drawn.
Monthly pension contributions from January to March, inclusive, would be delayed, with these becoming due in April. ....

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