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Malaria, the year of hope


3 May 2021
Results from the Oxford Jenner Institute trial of a malaria vaccine give it a 77% success rate. In a 2012 article detailing the many attempts to combat the disease, which kills more than 400,000 people a year, Pauline Léna commented that ‘the battle is as political as scientific. (.) While we await a technological solution, the efforts of governments and donors to improve access to treatment and the means of prevention remain the most effective weapon against this pandemic.’
Ten-year fight for world health
Malaria, the year of hope
Each minute, a child dies of malaria. Yet medicines exist. And a vaccine may come soon ....

France General , United States , Kenneth Arrow , Tu Youyou , Brian Greenwood , Institut Pasteur , Pierre Druilhe , Global Fund , London School Of Hygiene , Albert Lasker Award For Clinical Medical Research , Shoklo Malaria Research Unit , World Heath Organisation , John Hopkins Malaria Research Institute , Saharan Africa , Albert Lasker Award , Clinical Medical Research , Professor Fran , Affordable Medicines Facility , Malaria Venture , Professor Brian Greenwood , London School , பிரான்ஸ் ஜநரல் , ஒன்றுபட்டது மாநிலங்களில் , கெநெத் அம்பு , து நீங்கள் , பிரையன் கிரீன்வுட் ,

Human organ chips enable COVID-19 drug repurposing


 E-Mail
A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the Institute s organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19.
The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the process of evaluating the safety and efficacy of existing drugs for new medical applications, and provides a proof-of-concept for the use of Organ Chips to rapidly repurpose existing drugs for new medical applications, including future pandemics. The research is reported in
Nature Biomedical Engineering.
While many groups around the world have been testing existing drugs for efficacy against COVID-19 using cultured cells, it is well known that cells grown in a dish do not behave like the cells in a living human body, and many drugs that appear effective in lab studies do not work ....

United States , South Africa , South Korea , Amanda Jiang , Marisa Mcgrath , Rachelle Prantil Baun , Justin Frere , Shu Horiuchi , Ilona Golynker , Longlong Si , Steve Gygi , Wuji Cao , Girija Goyal , Kohei Oishi , Haiqing Bai , Sarah Gilpin , Daisy Hoagland , Benjamin Nilsson Payant , Danni Zhu , Ken Carlson , Robert Haupt , Kambez Benam , Atiq Nurani , Melissa Rodas , James Logue , Rasmus Moller ,

Drug-discovery collaboration finds potential new antimalarial drug candidates


Drug-discovery collaboration finds potential new antimalarial drug candidates
Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation.
A collaborative research team discovered compounds with antimalarial activity within a collection of 80,000 drug-like molecules in the Janssen Jump-stARter Compound Library, a unique collection of drug-like compounds designed to fast track the discovery of new medicines. Under the agreement, the most promising candidates are now being further developed by the researchers towards potential antimalarial drugs, which could lead to powerful new weapons in the global fight against this disease. ....

Brad Sleebs , Emily Henderson , Janssen Compound Library , Research Council , Australian National Health , Janssen Pharmaceutica , Compound Library , Malaria Venture , Professor Alan Cowman , Johnson Innovation , Janssen Discovery Chemistry , Target Product Profile , Professor Cowman , Ellen Corin Centenary Fellowship , Medical Research Council , Medical Research , Red Blood Cells , எமிலி ஹென்டர்சன் , ஆராய்ச்சி சபை , ஆஸ்திரேலிய தேசிய ஆரோக்கியம் , மலேரியா துணிகர , ப்ரொஃபெஸர் ஆலன் சவுமன் , ஜான்சன் கண்டுபிடிப்பு , இலக்கு ப்ராடக்ட் ப்ரொஃபைல் , மருத்துவ ஆராய்ச்சி சபை ,