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Computational Modeling in Medicine


Computational Modeling in Medicine
In the past few decades, information technology has revolutionized the medical industry. The accuracy with which biological systems and interactions can be simulated and data can be gathered have improved exponentially. Computational modeling has provided ever-more sophisticated data for the field of medical research. This article will discuss this subject.
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What is computational modeling?
Computational modeling is used to simulate and study complex systems using computer science, physics, and mathematics. Numerous variables are programmed into the computational model to characterize the system which is being studied. By adjusting these variables alone or in various combinations, the outcome can be observed, providing valuable data for researchers. ....

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With Release Of New Guidance Document FDA Launches Safer Technologies Program for Medical Devices


With Release Of New Guidance Document, FDA Launches Safer Technologies Program for Medical Devices
By Mark Durivage, Quality Systems Compliance LLC
The FDA’s Center for Devices and Radiological Health (CDRH) releasedthe
Safer Technologies Program for Medical Devices (STeP)
Guidance for Industry and Food and Drug Administration Staff on January 6, 2021, with plans to begin accepting applications for STeP beginning March 8, 2021. The two-month delay is due to the expected time to “operationalize” the program, which is a voluntary program applicable to “certain medical devices and device-led combination products that are reasonably expected to significantly improve the safety of currently available treatments or diagnostics that target an underlying disease or condition associated with morbidities and mortalities less serious than those eligible for the Breakthrough Devices Program.” ....

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FDA Opens the Pre-Sub Program to Compliance Actions, Including Form 483s and Warning Letters | Morgan Lewis


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Considering the tight timeline for preparing responses to FDA compliance actions coupled with the agency’s expectation for timely implementation of corrective and preventive actions, the benefit of obtaining feedback through the Q-submission program (also referred to as a “pre-submission”) may be limited.
To start off the new calendar year, FDA issued a revised version of its guidance document on the Q-submission program on January 6, 2021, “
Obtaining feedback on submissions that may qualify for FDA’s recently announced Safer Technologies Program (STeP), also launched on January 6, 2021 (see
Guidance Document). The STeP Program provides an expedited review and authorization process for certain device and device-led combination products that are reasonably expected to significantly improve the safety of currently available treatments or diagnostics that target an underlying disease or condition ....

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