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Targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers

Targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers
Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body s immune response.
A new study published in
Cell shows that endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection. Researchers suggest this mechanism could open new avenues for turning on the immune system in aggressive cancers like TNBC.
We know therapeutics that partially interfere with RNA splicing can have a very strong impact on tumor growth and progression, but the mechanisms of tumor killing are largely unknown. In this study, we discovered that these therapeutics are modulators of anti-tumor immunity, said Dr. Trey Westbrook, corresponding author of the study, execu ....

Jarey Wang , Trey Westbrook , Elizabeth Bowling , Emily Henderson , Therapeutic Innovation Center , Marrs Mclean Department Of Biochemistry , Study Co , Mcnair Scholar In Cancer Research At Baylor , Department Of Molecular , Baylor Medical Scientist Training Program , Researchers At Baylor College Of Medicine , Baylor College , Mcnair Scholar , Cancer Research , Study Co First Author , Baylor Medical Scientist Training , Welch Chair , Marrs Mclean Department , Molecular Biology , Human Genetics , Danl Duncan Comprehensive Cancer Center , Breast Cancer , Immune Response , Triple Negative Breast Cancer , Cell Death , Immune System ,

Triggering antiviral immune response in certain breast cancers

Date Time
Triggering antiviral immune response in certain breast cancers
Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body’s immune response. A new study published in Cell shows that endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection. Researchers suggest this mechanism could open new avenues for turning on the immune system in aggressive cancers like TNBC.
“We know therapeutics that partially interfere with RNA splicing can have a very strong impact on tumor growth and progression, but the mechanisms of tumor killing are largely unknown. In this study, we discovered that these therapeutics are modulators of anti-tumor immunity,” said Dr. Trey Westbrook, corresponding author of the study, executive director of the T ....

Jarey Wang , Trey Westbrook , Elizabeth Bowling , Therapeutic Innovation Center , Marrs Mclean Department Of Biochemistry , Mcnair Scholar In Cancer Research At Baylor , Department Of Molecular , Baylor Medical Scientist Training Program , Researchers At Baylor College Of Medicine , Baylor College , Mcnair Scholar , Cancer Research , Baylor Medical Scientist Training , Welch Chair , Marrs Mclean Department , Molecular Biology , Human Genetics , Danl Duncan Comprehensive Cancer Center , Baylor College Of Medicine , Immune Response , Breast Cancer , ட்ரே வெஸ்ட்புரூக் , எலிசபெத் பந்துவீச்சு , சிகிச்சை கண்டுபிடிப்பு மையம் , மார்ஸ் மக்லீந் துறை ஆஃப் உயிர் வேதியியல் , மக்நேர் அறிஞர் இல் புற்றுநோய் ஆராய்ச்சி இல் பேலர் ,

Triggering tumor antiviral immune response in triple negative breast cancer

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body s immune response. ....

United States , Baylor College Of Medicine , Jarey Wang , Trey Westbrook , Elizabeth Bowling , Therapeutic Innovation Center , Marrs Mclean Department Of Biochemistry , Mcnair Scholar In Cancer Research At Baylor , Department Of Molecular , Baylor Medical Scientist Training Program , Researchers At Baylor College Of Medicine , Baylor College , Mcnair Scholar , Cancer Research , Baylor Medical Scientist Training , Welch Chair , Marrs Mclean Department , Molecular Biology , Human Genetics , Danl Duncan Comprehensive Cancer Center , Cell Biology , Medicine Health , Breast Cancer , Clinical Trials , Pharmaceutical Science , ஒன்றுபட்டது மாநிலங்களில் ,