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Statistical Analysis
Three parallel experiments were performed to obtain the average value, which was determined using SPSS 23 statistical software and compared between groups using independent-sample t tests and a one-way analysis of variance method. Significant differences between groups were observed at the
P 0.05 level.
DPPH and ABTS Radical Scavenging Abilities of LPE
Figure 1 shows the dose-response relationship of DPPH and the ABTS radical scavenging ability of LPE. The ability of LPE to scavenge DPPH and ABTS radicals increased with increasing concentrations of LPE from 0 to 120 μg/mL. Moreover, the Vc positive control group had lower DPPH and ABTS radical scavenging abilities than LPE.
19,20 SPIOs have been widely examined for toxicological effects both in vitro and in vivo.
21–23 Mn-IONPs may exhibit totally different cytotoxicity, however, because Mn
2+-doping changes the crystal structure and increases the number of structural defects that disrupt the well structured electronic configuration of SPIO NPs.
18 Conceptually, the latent potential of Mn
2+ release allows the possibility of metal ion interaction with the intracellular components, which may result in the adverse effects on cell survival.
24,25 Thus, the biological effects of Mn-IONPs need to be specifically investigated. Until recently, researchers have examined the biocompatibility of Mn-IONPs and consistently found that they show a dose- and time-dependent cytotoxicity.