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Australian-led international research team generates first model of early human embryos from skin cells

Australian-led international research team generates first model of early human embryos from skin cells
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Scientists create model of an early human embryo from skin cells

Credit: Monash University
AUSTRALIAN - LED INTERNATIONAL RESEARCH TEAM GENERATES THE FIRST MODEL OF EARLY HUMAN EMBRYOS FROM SKIN CELLS
In a discovery that will revolutionize research into the causes of early miscarriage, infertility and the study of early human development - an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells.
The team, led by Professor Jose Polo, has successfully reprogrammed these fibroblasts or skin cells into a 3-dimensional cellular structure that is morphologically and molecularly similar to human blastocysts. Called iBlastoids, these can be used to model the biology of early human embryos in the laboratory. ....

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Scientists create model embryos in lab, raising major ethical questions

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Australian researchers have created “model” human embryos from the skin cells of an adult’s arm, in a world-first scientific breakthrough that raises significant ethical questions.
The model embryos, created in a laboratory by researchers at Melbourne’s Monash University, do not use egg or sperm, but ordinary cells that are reprogrammed to replicate the first few days of human life.
An animation, developed by Monash University, showing how the artificial embryos are generated.
Credit:Monash University
When placed in a dish, the model embryos attach – much as embryos would in the uterus – and begin developing.
However, they are not identical to natural embryos, lacking several key features and containing cells not normally seen. ....

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Scientists have created embryos. What does that mean? And what comes next?

Scientists have created embryos. What does that mean? And what comes next?
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Every cell in your body comes from a single cell: an egg, fertilised by a sperm. Each contains the exact same genetic blueprint for your life: your DNA.
Yet cells in your brain look and behave nothing like those in your muscle or skin.
Professor Jose Polo in front of images of his model embryos.
Credit:Monash University
Why? Because while each cell has the same instructions, each cell only reads certain sections â certain genes. A layer of what are called epigenetic instructions sit on top of your DNA, telling each cell which parts to read and which parts to ignore. ....

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Researchers create first model of early human embryos from skin cells

Monash University
Australian-led international research team generates the first model of early human embryos from skin cells
In a discovery that will revolutionise research into the causes of early miscarriage, infertility and the study of early human development – an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells.
The team, led by Professor Jose Polo, has successfully reprogrammed these fibroblasts or skin cells into a 3-dimensional cellular structure that is morphologically and molecularly similar to human blastocysts. Called iBlastoids, these can be used to model the biology of early human embryos in the laboratory. ....

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