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New functions of integrin and talin discovered by an international research network


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Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell membrane integrin receptors and contribute to the development of methods for the treatment of cancer.
In the cell membrane, integrins form the connection between the cytoskeleton and the extracellular matrix. The regulation of integrin activity is essential for the function of tissues and individual cells.
The studies investigated the structure and function of talin, a cytoskeletal protein, which is important in the regulation of the integrin receptor activity. Talin binds to integrin via its head and connects it to the cytoskeleton, thereby acting as a part of the cellular mechano-signalling network, which affects cell adhesion, migration, but also gene expression among other things. ....

Eteläuomen Läi , United States , United Kingdom , Sampo Kukkurainen , Latifeh Azizi , Bernhard Wehrle Haller , Ilpo Vattulainen , Markku Varjosalo , Professor Jinhua Wu Fox Chase Cancer Center , University Of Tampere Foundation , Cancer Foundation Finland , Proceedings Of National Academy Sciences , It Center , Anu Kirra Foundation , Biomedical Engineering At Tampere University , University Of Eastern Finland , Ben Goult University Of Kent , Researchers At Tampere University , Professor Bernhard Wehrle Haller University Of Geneva , University Of Helsinki , European Molecular Biology Laboratory , Tampere University , Doctoral Programme In Medicine , University Of Geneva , Academy Of Finland , Life Sciences ,