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La Jolla News Nuggets: Coast Walk Trail fundraiser, playhouse leaders, arts collection, more

La Jolla News Nuggets: Coast Walk Trail fundraiser, playhouse leaders, arts collection, more
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Study: Decreased activation of LEF1 gene disrupts ordinary neuronal function

Study: Decreased activation of LEF1 gene disrupts ordinary neuronal function Lithium is considered the gold standard for treating bipolar disorder (BD), but nearly 70 percent of people with BD don t respond to it. This leaves them at risk for debilitating, potentially life-threatening mood swings. Researchers at the Salk Institute have found that the culprit may lie in gene activity or lack of it. A new study led by Salk Professor and President Rusty Gage, which published in the journal Molecular Psychiatry on January 4, 2021, shows that decreased activation of a gene called LEF1 disrupts ordinary neuronal function and promotes hyperexcitability in brain cells a hallmark of BD. The work could result in a new drug target for BD as well as a biomarker for lithium nonresponsiveness.

La Jolla News Nuggets: Research ship, moon mission, restaurants, Bachelorette, more

RV Roger Revelle sent back to sea after extensive refit Research vessel Roger Revelle, one of the largest ships in the U.S. Academic Research Fleet, is back to sea after a $60 million refit involving upgrades from top to bottom, bow to stern. The refit will extend the service life by 15 to 20 years with improvements to systems crucial to the vessel’s operations, scientific capabilities, habitability and environmental footprint, according to the Scripps Institution of Oceanography at UC San Diego. The ship is owned by the Office of Naval Research and has been operated by Scripps Oceanography since 1996. The vessel is considered important to U.S. oceanographic research due to its range, payload, duration and ability to safely conduct scientific operations in remote areas around the globe.

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