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Science for just $15 USD. Summary A series of clinical trials is trying to determine whether changing participants lifestyles can curtail age-related cognitive decline or prevent dementia. Numerous observational studies suggest factors such as diet and exercise influence whether people develop dementia. But researchers have performed few randomized, controlled clinical trials that test the effects of altering these factors on mental capabilities, and many of the trials that have been conducted on individual risk factors were negative. Researchers now hope so-called multidomain trials can nail down whether modifying multiple risk factors benefits cognition. The first of these trials, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, showed a small cognitive benefit from an intensive program to improve lifestyle, and now trials are underway in the United States, Australia, and many other countries.View Full Text ....
Physical activity, a factor in healthy brain aging, is part of multidomain dementia prevention trials. ISTOCK.COM/KALI9 Can diet and exercise lower your risk of dementia? Rigorous clinical trials aim to find out May. 27, 2021 , 1:00 PM For the past 3 years, about 6000 middle-aged and elderly Australians have pumped iron, loaded up on greens and whole grains, strived to quell stress, and challenged their wits with computer exercises, all in an effort to preserve their cognition. They’re part of a clinical trial called Maintain Your Brain, one of about 30 current or planned studies that eschew pharmaceutical interventions and test whether altering multiple aspects of participants’ lives improves brain health. Such multidomain studies may finally reveal whether modifying diet, exercise, and other factors can slow cognitive decline as people age or even prevent dementia. ....