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HEXAOM : Présentation Réunion SFAF 21/09/2021Fichier pdf - 22,22 Mo

HEXAOM : Présentation Réunion SFAF 21/09/2021Fichier pdf - 22,22 Mo
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Frontiers | Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus


2School of Biological Sciences, University of Western Australia, Crawley, WA, Australia
3Perron Institute for Neurological and Translational Research, Crawley, WA, Australia
Tinnitus, a phantom auditory perception that can seriously affect quality of life, is generally triggered by cochlear trauma and associated with aberrant activity throughout the auditory pathways, often referred to as hyperactivity. Studies suggest that non-auditory structures, such as prefrontal cortex (PFC), may be involved in tinnitus generation, by affecting sensory gating in auditory thalamus, allowing hyperactivity to reach the cortex and lead to perception. Indeed, human studies have shown that repetitive transcranial magnetic stimulation (rTMS) of PFC can alleviate tinnitus. The current study investigated whether this therapeutic effect is achieved through inhibition of thalamic hyperactivity, comparing effects of two common clinical rTMS protocols with sham treatment, in a guinea pig tinnitus ....

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