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Delix Therapeutics Announces Scientific & Strategic Advisory Board Appointments

Cerebral hemorrhage linked to stroke, cardiac risks

May 4, 2021 People who have experienced a cerebral hemorrhage or brain bleed have a two-fold increase in the risk of having an ischemic stroke (caused by an artery blockage) or heart attack, compared with members of the general population, according to new research from investigators at Weill Cornell Medicine and NewYork-Presbyterian. The researchers said the findings, published May 3 in JAMA Neurology, have broad implications for the monitoring and treatment of patients who have experienced cerebral hemorrhage and brain bleeds. “These findings are contrary to the conventional wisdom, because somebody who has had a brain bleed is believed to be at higher risk for subsequent brain bleeds, but not necessarily clotting events,” said lead author Dr. Santosh Murthy, assistant professor of neurology at Weill Cornell Medicine and the medical director of the Neurological Intensive Care Unit at NewYork-Presbyterian/Weill Cornell Medical Center. “These findings suggest that we need

Neuroscience edges closer to high-res mammalian brain atlas

By March 11, 2021 A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain. Isoform variation is a process that extends the versatility of DNA by enabling individual genes to give rise to multiple versions of a protein, each of which may have a different function. Genes, when active, are transcribed into RNA molecules, and isoform variation involves the dicing and splicing into alternate versions or isoforms of these RNA molecules, each corresponding to a distinct variant of a protein.

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