Monash University
Researchers from Monash University make a breakthrough discovery into how migraines are triggered
World first: Researchers from Monash University have harnessed cutting-edge technology to discover the progression of molecular events that lead to migraine – something that, until now, has remained a mystery.
The discovery has filled one of the most important gaps in our understanding of how migraines are activated.
Published today in the prestigious journal Science, the breakthrough study was led by a team of researchers from the Monash Institute of Pharmaceutical Sciences (MIPS) and the recently established ARC Centre for Cryo-EM of Membrane Proteins (CCeMMP).
One of the most common causes for migraine is abnormal levels of activation of the target for an extremely potent vascular regulator, calcitonin gene-related peptide (CGRP). The newest and most exciting treatments for migraine act by blocking this activity, but how CGRP activates its receptor at the mole