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Feb 26, 2021 Biliary complications significantly reduced with hypothermic oxygenated machine perfusion The waiting list for liver transplants is long and the Americans who die on that list number in the thousands because there are too few donor organs, but machine cold perfusion may ease the supply deficit. Organs for liver transplant come from living donors and brain-dead donors. Another source is organs harvested from donors after circulatory death (DCD), which currently make up about 25% of transplanted livers. But patients who received DCD grafts are at risk for worse outcome due to ischemia-reperfusion injury, which can result in bile-duct injury and lead to nonanastom0tic biliary strictures. ....
Vaccine Fails to Prevent Chronic HCV Infection physiciansweekly.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from physiciansweekly.com Daily Mail and Mail on Sunday newspapers.
Feb 5, 2021 Volume, volume, volume may be the answer As findings from trial after trial provide evidence of the clinical benefit of SGLT2 inhibition in patients with reduced ejection fraction heart failure (HFrEF) DAPA-HF, EMPIRE-HF, EMPEROR-Reduced, there is little convincing left to do about the value of adding SGLT2 inhibitors to the HF armamentarium, as demonstrated by their inclusion in an updated expert decision pathway issued by the American College of Cardiology in early January 2021. But exactly why these drugs provide these demonstrable benefits is still debatable. Jesper Jensen, MD, PhD, of Herlev and Gentofte University Hospital, Herlev, Denmark, and University of Copenhagen, Copenhagen, Denmark, and colleagues drilled down into data from a prespecified substudy of EMPIRE-HF (EMPIRE-HF Renal) to investigate the “effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate (GFR) in pat ....
Jan 12, 2021 Consistent benefit regardless of CKD etiology Once, in the not-too-distant past, one could not scan the latest issue of any top-tier medical journal without finding at least one trial extolling the benefits of statin therapy, which lead many to suggest and not always facetiously that it was time to add statins to the water. Since late summer 2019 when the results of DAPA-HF were reported at the 2019 European Society of Cardiology Congress in Paris, SGLT2 inhibitors have displaced statins as the pharmaceutical of choice for those who like the “one-drug-fits-all-conditions” approach to the art of medicine. The latest entry comes from David C. Wheeler, MB, ChB, MD of the George Institute for Global Health in Sydney, Australia, who with his co-investigators offers another look at the findings from DAPA-CKD in ....
Jan 1, 2021 But if rivaroxaban is ’in’, is DAPT ’out’? The introduction of direct oral anticoagulants (DOACs) in 2010 significantly changed clinical algorithms for prevention of VTE and stroke, as well as management of atrial fibrillation. In this report, which was initially published March 29, 2020, researchers presented findings that support a role for rivaroxaban in revascularization procedures in patients with PAD. BreakingMED is republishing this report as part of its year end clinical review series. Findings from a trial of more than 6,564 patients undergoing revascularization procedures for peripheral artery disease are likely to change clinical practice, signaling a death knell for dual antiplatelet therapy while boosting the use of direct oral anticoagulant (DOAC) therapy in these patients. ....