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GHIT Fund Announces New Investment: 97.4 Million Yen to Identify Novel Dual-Acting Bactericidal Drug Targets Against Mycobacterium Tuberculosis


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TOKYO, July 14, 2021 /PRNewswire/ The Global Health Innovative Technology (GHIT) Fund announced today a total of approximately 97.4 million yen (US$0.88 million ) to invest in a drug discovery project for tuberculosis (TB), which will be conducted by an academic partnership comprised of highly skilled experts in bacterial genetics, bacterial physiology, chemical biology, medicinal chemistry and pharmaceutical sciences in Japan and the United States.
Portfolio analysis of active and completed projects. All amounts are listed at the exchange rate of USD1 = JPY110.61, the approximate exchange rate on June 30, 2021.
This new project of the GHIT Target Research Platform aims to identify novel targets for TB drugs that can rapidly and strongly kill ....

Bumpei Tamamura , Katy Lenard , United Nations Development Programme , Fujita Health University , Melinda Gates Foundation , Hokkaido University , Nagoya University , Harvard University , Research Institute Of Tuberculosis , University Of Minnesota , Research Platform , Target Research Platform , Health University , Research Institute , ஒன்றுபட்டது நாடுகள் வளர்ச்சி ப்ரோக்ராம் , புஜிதா ஆரோக்கியம் பல்கலைக்கழகம் , மெலிண்டா வாயில்கள் அடித்தளம் , ோக்கைடோ பல்கலைக்கழகம் , நாகோயா பல்கலைக்கழகம் , ஹார்வர்ட் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் மினசோட்டா , ஆராய்ச்சி நடைமேடை , இலக்கு ஆராய்ச்சி நடைமேடை , ஆரோக்கியம் பல்கலைக்கழகம் , ஆராய்ச்சி நிறுவனம் ,

Therapy and prevention of Alzheimer's disease


D) Aβ
1-42 (red lines). Relative Aβ amount changes during treatment with concomitant use of HexDC and the PSf hemodialyzer (HexDC+Dialyzer) (
A and
C, pale green background). Relative Aβ amount changes during treatment with PSf hemodialyzer alone (Dialyzer only) (
B and
D, light orange background). Solid lines with triangle symbols, relative Aβ amounts removed by HexDC; dotted lines with cross square marks, relative Aβ amounts removed by PSf hemodialyzer; dashed lines with circle symbols, relative Aβ amounts decreased in the plasma.
Relative Aβ amounts removed by HexDC and PSf dialyzers (solid lines and dotted lines in Figure 13, respectively) increased time-dependently. This suggests that HexDC and PSf dialyzers had adequate Aβ adsorption capacity during the 4 and 8 h treatments. However, the changes were smaller in the latter half of the treatment than in the first half. The relative decreases in plasma Aβ (dashed lines under 0% in Figure 13) s ....

United States , Eteläuomen Läi , Fujita Health University , Institute Inc , Good Clinical , Asahi Kasei Medical , Designspark Mechanical , Coriolis Flow Meter , Masterflex Variable Speed Drive , Hemodialysis Patients Using , Subjects Undergoing Blood , Blood Concentrations , High Sensitive Human , Pump Adsorptive Filtration Systems , Hemodialyzers Alone , Blood While Using Different , Dialyzer Only , ஒன்றுபட்டது மாநிலங்களில் , புஜிதா ஆரோக்கியம் பல்கலைக்கழகம் , நிறுவனம் இன்க் , நல்ல மருத்துவ , கோரியோலிஸ் ஓட்டம் மீட்டர் ,