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TOKYO, July 14, 2021 /PRNewswire/ The Global Health Innovative Technology (GHIT) Fund announced today a total of approximately 97.4 million yen (US$0.88 million ) to invest in a drug discovery project for tuberculosis (TB), which will be conducted by an academic partnership comprised of highly skilled experts in bacterial genetics, bacterial physiology, chemical biology, medicinal chemistry and pharmaceutical sciences in Japan and the United States.
Portfolio analysis of active and completed projects. All amounts are listed at the exchange rate of USD1 = JPY110.61, the approximate exchange rate on June 30, 2021.
This new project of the GHIT Target Research Platform aims to identify novel targets for TB drugs that can rapidly and strongly kill
D) Aβ
1-42 (red lines). Relative Aβ amount changes during treatment with concomitant use of HexDC and the PSf hemodialyzer (HexDC+Dialyzer) (
A and
C, pale green background). Relative Aβ amount changes during treatment with PSf hemodialyzer alone (Dialyzer only) (
B and
D, light orange background). Solid lines with triangle symbols, relative Aβ amounts removed by HexDC; dotted lines with cross square marks, relative Aβ amounts removed by PSf hemodialyzer; dashed lines with circle symbols, relative Aβ amounts decreased in the plasma.
Relative Aβ amounts removed by HexDC and PSf dialyzers (solid lines and dotted lines in Figure 13, respectively) increased time-dependently. This suggests that HexDC and PSf dialyzers had adequate Aβ adsorption capacity during the 4 and 8 h treatments. However, the changes were smaller in the latter half of the treatment than in the first half. The relative decreases in plasma Aβ (dashed lines under 0% in Figure 13) seemed to plateau afte