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Small PFS Bump in Synovial Sarcoma With Novel Drug

But questions raised over control arm and whether improvement represents a meaningful benefit ....

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Two-drug combo starves bone cancer cells to death

Starving cancer cells of the energy they need to grow could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, according to a new study.
Studying human cancer cells and mice, researchers report that a two-drug combination targeting a tumor’s energy sources could prove as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer.
Osteosarcoma is the most common tumor of the bone in adults and children. It accounts for about 4% of all pediatric cancers and more than half of all pediatric bone cancers. Standard treatment for osteosarcoma includes surgery, radiation, and a cocktail of chemotherapy drugs including high-dose methotrexate, which can cause liver and kidney damage. ....

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Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests | The Source

Two drugs targeting cancer cells’ energy source potentially could replace toxic chemo in osteosarcoma
January 26, 2021
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A new study from Washington University School of Medicine in St. Louis suggests that a two-drug combination targeting a tumor’s energy sources could be as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer. Shown is a cross section of osteosarcoma. (Image: Richa Rathore)
An innovative approach to treating bone tumors starving cancer cells of the energy they need to grow could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. Studying human cancer cells and mice, the researchers said that a two-drug combination targeting a tumor’s energy sources could be as effective and less toxic than methotrexate, a l ....

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Nixing bone cancer fuel supply offers new treatment approach: study - World News

2021-01-27 18:36:00 GMT2021-01-28 02:36:00(Beijing Time) Xinhua English
CHICAGO, Jan. 27 (Xinhua) A study of Washington University School of Medicine in St. Louis suggests that an innovative approach to treating bone tumors, starving cancer cells of the energy they need to grow, may one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects.
The researchers studied an investigational drug called NCT-503, a member of a relatively new class of drugs called PHGDH inhibitors that have gained interest as potential metabolic therapies for cancer. This investigational drug prevents cancer cells from manufacturing the amino acid serine, a source of energy that fuels cancer growth. ....

United States , Richa Rathore , Washington University School Of Medicine , Washington University School , Brian Van Tine , ஒன்றுபட்டது மாநிலங்களில் , ரிச்சா ரதோரே , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , பிரையன் வேன் டைன் ,

Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests – Washington University School of Medicine in St. Louis

Richa Rathore
A new study from Washington University School of Medicine in St. Louis suggests that a two-drug combination targeting a tumor’s energy sources could be as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer. Shown is a cross section of osteosarcoma.
An innovative approach to treating bone tumors – starving cancer cells of the energy they need to grow – could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. Studying human cancer cells and mice, the researchers said that a two-drug combination targeting a tumor’s energy sources could be as effective and less toxic than methotrexate, a long-used chemotherapy drug often given in high doses to treat osteosarcoma, a bone cancer. ....

Julia Evangelou Strait , Richa Rathore , Siteman Cancer Center At Barnes , Washington University School Of Medicine , Washington University School , Brian Van Tine , Van Tine , Young Adult Sarcoma , Siteman Cancer Center , Barnes Jewish Hospital , Siteman Kids , Louis Children , ரிச்சா ரதோரே , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , பிரையன் வேன் டைன் , வேன் டைன் , களஞ்சியங்கள் நகை மருத்துவமனை , லூயிஸ் குழந்தைகள் ,