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University of São Paulo: "Rafts" in neurons are key to understanding the action of antidepressants – India Education,Education News India,Education News


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Rspecialized regions in the membrane of nervous system cells, rich in cholesterol and known as lipid rafts – lipid rafts, in English – may be the key to understanding the action of antidepressant drugs. In a study with the participation of the Ribeirão Preto School of Medicine (FMRP) at USP, scientists found that the level of cholesterol in these regions of the cell membrane determines the structure and functioning of a receptor, a protein that serves as a target for antidepressants in neurons. The research is described in an article published in the scientific journal Cell .
“For the study, several classes of antidepressants were used, including classic drugs, such as fluoxetine and imipramine, and the fast-acting antidepressants, discovered more recently, such as ketamine,” says researcher Cassiano Ricardo Alves to Jornal da USP Faria Diniz, who is doing post-doctoral studies at FMRP and participated in the work. “From in vitro, laboratory, and in silico ....

Eteläuomen Läi , Cassiano Diniz , Caroline Biojone , Paulo Fapesp , Eero Castr , Cassiano Ricardo Alves , Faria Diniz , University Of Helsinki Finland , University Of Helsinki , Pharmacology Department , Department Of Physics , Research Support Foundation , Department Of Pharmacology , Preto School Of Medicine , Preto School , Professor Eero Castr , State Research Support Foundation , காசியானோ டிநிஸ் , காசியானோ ரிக்கார்டோ ஆல்வ்ஸ் , பரிய டிநிஸ் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி பின்லாந்து , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , மருந்தியல் துறை , துறை ஆஃப் இயற்பியல் , ஆராய்ச்சி ஆதரவு அடித்தளம் , துறை ஆஃப் மருந்தியல் ,