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University of Helsinki: Ad­vanced imaging technology cap­tures trans­la­tion of the ma­ter­nal gen­ome


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An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases.
There is a familiar saying, “It’s all in the genes”. As modern archaeology reveals, the DNA that encodes genes can be found among the remnants of our ancestors and from any organism, small and large, that once roamed the earth. The genetic blueprint alone is not sufficient; life requires the faithful expression and translation of our genomes. Basic research in molecular biology has revealed in beautiful detail the mechanisms by which these fundamental processes operate. One of these p ....

United States , Eteläuomen Läi , United Kingdom , Karolinska Institutet , Uwe Richter , Jacques Monod , Brendan Battersby , Newcastle University , University Of Helsinki , Alexey Amunts At Stockholm University , University Of Miami Miller School Medicine , Nobel Prize , Alexey Amunts , Stockholm University , Professor Antoni Barrientos , Miami Miller School , Principal Investigator , Research Director Brendan Battersby , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , ய்வ் பணக்காரர் , பிரெண்டன் பாட்டெர்ஸப்ய , நியூகேஸில் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , பல்கலைக்கழகம் ஆஃப் மியாமி மில்லர் பள்ளி மருந்து , நோபல் ப்ரைஸ் ,

Advanced imaging technology captures translation of the maternal genome


Credit: A. Amunts and D. Nowakowski
An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases.
There is a familiar saying, It s all in the genes . As modern archaeology reveals, the DNA that encodes genes can be found among the remnants of our ancestors and from any organism, small and large, that once roamed the earth. The genetic blueprint alone is not sufficient; life requires the faithful expression and translation of our genomes. Basic research in molecular biology has revealed in beautiful detail the mechanisms by which these fundamental proce ....

United States , Eteläuomen Läi , United Kingdom , Karolinska Institutet , Uwe Richter , Jacques Monod , Brendan Battersby , Newcastle University , University Of Helsinki , Alexey Amunts At Stockholm University , University Of Miami Miller School Medicine , Nobel Prize , Alexey Amunts , Stockholm University , Professor Antoni Barrientos , Miami Miller School , Principal Investigator , Research Director Brendan Battersby , Cell Biology , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , ய்வ் பணக்காரர் , பிரெண்டன் பாட்டெர்ஸப்ய , நியூகேஸில் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி ,