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Hessen verbietet Lernmethode „Schreiben nach Gehör"

Hessen verbietet Lernmethode „Schreiben nach Gehör"
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Anti-diarrhoea drug drives cancer cells to cell death – Aktuelles aus der Goethe-Universität Frankfurt

Anti-diarrhoea drug drives cancer cells to cell death – Aktuelles aus der Goethe-Universität Frankfurt
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Muriel Mari , Nina Meyer , Maximiliann Kinzler , Svenja Zielke , Sjoerd Van Wijk , Fulvio Reggiori , Simon Kardo , Alexandra Stolz , Simone Fulda , Adriana Covarrubias Pinto , German Research Foundation Deutsche Forschungsgemeinschaft , Frankfurt Foundation For Children , Goethe University , Collaborative Research Centre , Professor Fulvio Reggiori University Of Groningen , Experimental Cancer Research , Frankfurt Foundation , Frankfurter Stiftung , Functional Characterisation , German Research Foundation , Deutsche Forschungsgemeinschaft , Professor Fulvio Reggiori , Experimental Neurosurgery , Laura Zein , Francis Online , ம்யூரீயல் மாரி ,

Anti-diarrhoea drug drives cancer cells to cell death

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The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe University already two years ago found evidence indicating that the anti-diarrhoea drug loperamide could be used to induce cell death in glioblastoma cell lines. They have now deciphered its mechanism of action and, in doing so, are opening new avenues for the development of novel treatment strategies.
When cells digest themselves
In certain types of tumour cells, administration of loperamide leads to a stress response in the endoplasmic reticulum (ER), the cell organelle responsible for key steps in protein synthesis in the body. The stress in the ER triggers its degradation, followed by self-destruction of the cells. This mechanism, known as autophagy-dependent cell death occurs when cells undergo hyperactivated autophagy. Normally, autophagy regulates normal metabolic processes and breaks down and recycles the valuable parts of damaged or ....

Muriel Mari , Sjoerd Van Wijk , German Research Foundation Deutsche Forschungsgemeinschaft , Frankfurt Foundation For Children , Goethe University , Collaborative Research Centre , Professor Fulvio Reggiori University Of Groningen , Experimental Cancer Research , Frankfurt Foundation , Frankfurter Stiftung , Functional Characterisation , German Research Foundation , Deutsche Forschungsgemeinschaft , Professor Fulvio Reggiori , Experimental Neurosurgery , ம்யூரீயல் மாரி , பிராங்க்ஃபர்ட் அடித்தளம் க்கு குழந்தைகள் , கோதீ பல்கலைக்கழகம் , கூட்டு ஆராய்ச்சி மையம் , சோதனை புற்றுநோய் ஆராய்ச்சி , பிராங்க்ஃபர்ட் அடித்தளம் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , சோதனை நரம்பியல் அறுவை சிகிச்சை ,