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Complications Develop in Half of COVID-19 Cases Treated in Hospitals
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Nearly half of patients hospitalized with COVID-19 experienced at least one complication, researchers found in a prospective study.
There were 49.7% of patients overall who developed one or more COVID-19 complications, and 43.5% of survivors with a minimum of one complication, reported Ewen M. Harrison, MBChB, PhD, from the University of Edinburgh in Scotland, and colleagues.
Men and adults older than age 60 were most likely to have a complication from COVID-19, with complications reported in 54% of men and 48% of women older than age 60, authors wrote in
The most frequent COVID-19 complications were renal (24.3%), respiratory (18.4%), and systemic (16.3%). Additional complications were cardiovascular (12.3%), neurological (4.3%), and gastrointestinal (10.8%) complications.
News Scan for Jul 16, 2021
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Analysis of 10 studies shows ivermectin not effective in treating COVID-19
A new meta-analysis of 10 studies shows ivermectin (IVM), an anti-parasite drug, is not an effective treatment for COVID-19 and is not a viable treatment option for patients. The study was published yesterday in
Clinical Infectious Diseases.
The authors analyzed results from 10 randomized control trials (RCTs) that included 1,173 patients total, and looked for IVM s effect on all-cause mortality, length of hospital stay, adverse events, and viral clearance compared to standard of care.
COVID-19 patients had mild disease in 8 of the trials, moderate in 1 trail, and mild to moderate in 1 trial.
IVM did not reduce all-cause mortality when compared to controls (relative risk, 0.37; 95% confidence interval [CI], 0.12 to 1.13) or length of stay versus controls (0.72 days, 95% CI, −0.86 to 2.29). Adverse events, severe adverse events, and viral clearance were similar between IVM and controls, the authors foun
See eTable 1 in Supplement 2 for definitions of each analysis population. Among those receiving aluminum hydroxide (alum) for the first dose, 5 participants received WIV04 (n = 2) and HB02 (n = 3) vaccines for the second dose and were not included in the safety analysis population of the alum-only group (13 458 – 5 = 13 453), but were included in the WIV04 and HB02 groups, respectively. Three participants who received WIV04 for the first dose and HB02 for the second dose and 3 participants who received HB02 for the first dose and WIV04 for the second dose were included in both groups (WIV04: 13 459 + 2 + 3 = 13 464; HB02: 13 465 + 3 + 3 = 13 471). To measure neutralization antibody levels, the first 900 participants from each study site were selected. There were 9 participants in the WIV04 group, 7 in the HB02 group, and 8 in alum-only group who had adverse events or serious adverse events (SAEs) after the first dose and did not receive the secon
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