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How to Optimize Success in Clinical Trials of Antidepressants


How to Optimize Success in Clinical Trials of Antidepressants
By Paula Jacobsen, Ph.D., and Nick DeMartinis, M.D., Praxis Precision Medicines
This is an exceptionally exciting time to be developing therapies for patients suffering from depressive disorders. Advances in antidepressant pharmacology have led to diverse and promising therapeutic options. However, it is important to acknowledge the challenges of conducting clinical trials for major depressive disorder (MDD).
Chief among these challenges is the sensitivity of clinical trial methodology for demonstration of efficacy in MDD. A meta-analysis of antidepressant programs that included FDA-approved antidepressant clinical trial data from randomized, double-blind, placebo-controlled acute treatment studies conducted between 1995 and 2008 revealed that only 50% were successful despite the inclusion of only studies that evaluated doses in the approved therapeutic range. ....

United States , Georgia Institute Of Technology , Clin Neurosci , Clin Pharmacol , Mhealth Uhealth , Clin Psychopharmacol , Paula Jacobsen , Nick Demartinis , University Of Pennsylvania School Medicine , Human Services , College Of Georgia , World Health Organization , Drug Administration , Central College , Registration Statement For Praxis Precision Medicines Inc , Overlapping Challenges For Medications Development , Placebo Group , University Of Texas , Us Department Of Health , Uconn School Of Medicine , Loyola University Chicago , Praxis Precision , Intentionally Non Adherent , Sequential Parallel Comparison Design , Adherence Monitoring , Undiminished Participation ,

Ankle Treatment Study Included in New U.S. Physical Therapy Guidelines


2 Min Read
Published on: 20 hours ago
Findings by Loma Linda University researchers on lateral ankle sprains have been included in two new clinical practice guidelines established by the American Physical Therapy Association (APTA).
Researchers from the Physical Therapy department of Loma Linda University School of Allied Health Professions in Loma Linda, California, United States, identified an alternative approach to help clinicians examine and treat patients with chronic lateral ankle sprains and instability. They found that muscular impairments in the hip are associated with abnormal movement patterns in those individuals with chronic ankle sprains. Based on their study results, researchers recommend clinicians include hip muscle performance in the assessment protocol and support interventions, with a special focus on the inclusion of hip muscles when treating patients with chronic ankle sprains. ....

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Eisai Presents Breadth of Data Across Neurology Portfolio, Including Alzheimer's Disease, Insomnia and Epilepsy


Eisai Presents Breadth of Data Across Neurology Portfolio, Including Alzheimer s Disease, Insomnia and Epilepsy
Twenty-one presentations featuring data and information on investigational lecanemab in early Alzheimer s disease, DAYVIGO® (lemborexant) CIV in insomnia, FYCOMPA® (perampanel) CIII in epilepsy and investigational lorcaserin in Dravet Syndrome
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WOODCLIFF LAKE, N.J., April 16, 2021 /PRNewswire/ Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., announced today that data from the company s deep neurology pipeline and portfolio, including Alzheimer s disease, insomnia and epilepsy, will be presented at the 73
rd Annual Meeting of the American Academy of Neurology (AAN), taking place virtually from April 17-22, 2021. ....

United States , New Jersey , North Carolina , Gary Zammit , Shau Yu Lynch , Alzheimers Dement , Ryan Husni , Genevieve Meier , Carmen Castrillo Viguera , Craig Chepke , Ivan Cheung , Chris Vancheri , Michael Irizarry , Russell Rosenberg , Rakeh Jain , Rohit Shankar , National Institute On , Biogen Inc , Prnewswire Eisai Inc , European Union , Us Drug Enforcement Administration , Eisai Tsukuba Research Laboratories , Meeting Of The American Academy Neurology , National Institutes Of Health , Epilepsy Foundation , Drug Administration ,

HERO: Despite Retiring, Former Teacher Still Helping Kids


And even after I retired, I missed the kids,  Nancy Donahue says.
Donahue taught third grade at Tropical Elementary for 12 years. After retiring, she subbed and tutored, still making a difference in children s lives.
Donahue got on teacher-related social media sites for her to continue to learn and grow.
That s how I met this teacher from Africa, she says. I had been studying with my students about Malawi.
Temwani too, was a third-grade teacher with 264 students. Yes, 264 by herself.
Donahue jumped in and asked how she could help.
She said pens, I said, ‘Writing pens?’ Donahue recalls.  She said, Yes, the students don t have pens to take exams. ” ....

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