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Researchers Identify a New, Vital Player in Graft-Versus-Host Disease and Organ Transplant Rejection

Researchers Identify a New, Vital Player in Graft-Versus-Host Disease and Organ Transplant Rejection
How one long noncoding RNA could help improve outcomes in bone marrow and solid organ transplantation.
Credit: Michigan Medicine
A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation.
This RNA molecule, cataloged in scientific databases simply as Linc00402, helps activate immune defenders known as T cells in response to the presence of foreign human cells, according to a new study by researchers at the University of Michigan Rogel Cancer Center and Michigan Medicine. ....

United States , Daniel Peltier , Pavan Reddy , University Of Michigan Rogel Cancer Center , Rogel Cancer Center , Michigan Rogel Cancer Center , Science Translational , ஒன்றுபட்டது மாநிலங்களில் , டேனியல் பெழ்திிேர் , பவன் சிவப்பு , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் ரோஜல் புற்றுநோய் மையம் , ரோஜல் புற்றுநோய் மையம் , மிச்சிகன் ரோஜல் புற்றுநோய் மையம் , அறிவியல் மொழிபெயர்ப்பு ,

A new, vital player in graft-versus-host disease and organ transplant rejection

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A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation.
This RNA molecule, cataloged in scientific databases simply as Linc00402, helps activate immune defenders known as T cells in response to the presence of foreign human cells, according to a new study by researchers at the University of Michigan Rogel Cancer Center and Michigan Medicine.
The investigation, which included samples from more than 50 patients who underwent a bone marrow or heart transplant, suggests inhibiting the RNA therapeutically might improve outcomes for transplant recipients. Their findings appear in ....

Michigan Center , United States , Cynthia Zajac , Julia Wu , Guoqing Hou , Visweswaran Ravikumar , Hideaki Fujiwara , Austin Taylor , Daniel Goldstein , Stephanie Kim , Molly Radosevich , Sherric Wood , Thomas Decoville , David Sokol , Arvind Rao , Pavan Reddy , Yaping Sun , Arul Chinnaiyan , Katherine Oravecz Wilson , Daniel Peltier , Sethuramasundaram Pitchiaya , Baldrick Foundation Fellowship , National Institutes Of Health , Rogel Cancer Center , University Of Michigan Rogel Cancer Center , Department Of Defense Idea Development Award ,

A new, vital player in graft-versus-host disease and organ transplant rejection

A new, vital player in graft-versus-host disease and organ transplant rejection
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Michigan Center , United States , Cynthia Zajac , Julia Wu , Guoqing Hou , Visweswaran Ravikumar , Hideaki Fujiwara , Austin Taylor , Daniel Goldstein , Stephanie Kim , Molly Radosevich , Sherric Wood , Thomas Decoville , David Sokol , Arvind Rao , Pavan Reddy , Yaping Sun , Arul Chinnaiyan , Katherine Oravecz Wilson , Daniel Peltier , Sethuramasundaram Pitchiaya , Baldrick Foundation Fellowship , National Institutes Of Health , Rogel Cancer Center , University Of Michigan Rogel Cancer Center , Department Of Defense Idea Development Award ,

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Pavan Reddy , District Tadapatri , பவன் சிவப்பு ,