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New oral drug can stop tumours from growing-546359


New oral drug can stop tumours from growing
Sun Online Desk
 
US researchers have found that an oral drug can be effective in stopping tumours from growing.
The team from the University of Colorado Cancer Center found that slowing down NLRP3 can reduce inflammation and curb tumour growth and progression.
“NLRP3 is a member of a larger family that is involved in sensing danger signals,” said Carlo Marchetti, from the varsity’s School of Medicine.
“It is a receptor that surveils the intercellular compartment of a cell, looking for danger mlecules or pathogens.
“When NLRP3 recognises these signals, it leads to the activation of caspase-1, a protein involved in the processing and maturation of interleukin-1-beta into its biological active form, causing an intense inflammatory response. We found that in melanoma, this process is dysregulated, resulting in tumour growth,” Marchetti said. ....

United States , Carlo Marchetti , School Of Medicine , University Of Colorado Cancer Center , Colorado Cancer Center , ஒன்றுபட்டது மாநிலங்களில் , கார்லோ மார்ச்செட்டி , பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் கொலராடோ புற்றுநோய் மையம் , கொலராடோ புற்றுநோய் மையம் ,

Inhibition of NLRP3 complex can reduce inflammation in melanoma patients


Inhibition of NLRP3 complex can reduce inflammation in melanoma patients
Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center.
In a paper published in the journal
PNAS last month, CU Cancer Center members Mayumi Fujita, MD, PhD, Angelo D Alessandro, PhD, Morkos Henen, PhD, MS, Beat Vogeli, PhD, Eric Pietras, PhD, James DeGregori, PhD, Carlo Marchetti, PhD, and Charles Dinarello, MD, along with Isak Tengesdal, MS, a graduate student in the Division of Infectious Diseases at the University of Colorado School of Medicine, detail their work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. ....

United States , Eric Pietras , Charles Dinarello , James Degregori , Emily Henderson , Morkos Henen , Carlo Marchetti , Mayumi Fujita , Angelo Dalessandro , University Of Colorado , University Of Colorado School Medicine , University Of Colorado Cancer Center , Division Of Infectious Diseases , Cu Cancer Center , Colorado Cancer , Angelod Alessandro , Beat Vogeli , Isak Tengesdal , Infectious Diseases , Colorado School , ஒன்றுபட்டது மாநிலங்களில் , ஜேம்ஸ் டெக்ரேகோரி , எமிலி ஹென்டர்சன் , கார்லோ மார்ச்செட்டி , மயூமி புஜிதா , ஏஞ்சலோ டாப்லெஸ்ஸான்றோ ,

Colorado US Navy Veterans Mesothelioma Advocate Recommends Attorney Erik Karst of Karst von Oiste for a Navy Veteran or Person with Mesothelioma or Their Family-Compensation Might Exceed $1,000,000