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Spontaneous cell fusions amplify genetic diversity within tumors, Moffitt researchers say


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TAMPA, Fla. Evolution within groups of tumor cells follows the principles of natural selection, as evolution in pathogenic microbes. That is, the diversity of cellular characteristics within a group leads to differences in the ability of cells to survive and divide, which leads to selection for cells that bear characteristics that are most fit to the malignant environment. The ability to continuously create a diverse set of new cellular features enables cancers to develop the ability to grow in new tissue environments and to acquire resistance to anti-cancer drugs. The diversity of cell characteristics within groups of cancer cells can be created by a number of well-characterized mechanisms, including small-scale mutations, large-scale genomic changes involving losses, gains and reshuffling of large pieces of DNA, as well as by nongenetic mechanisms that create lasting changes in cellular features. At the same time, scientists generally believe that cancers lack a p ....

United States , Susang Komen , Andriy Marusyk , Revolution Program , National Cancer Institute , Cancer Physiology Department At Moffitt , Moffitt Cancer Center , Florida Bankhead Coley Cancer Research Program , American Cancer Society , Nature Ecology , Cancer Physiology Department , Cancer Physiology , Integrated Mathematical Oncology , Bankhead Coley Cancer Research Program , Cancer Biology , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , சுசாங் கோமேன் , பரிணாமம் ப்ரோக்ர்யாம் , தேசிய புற்றுநோய் நிறுவனம் , புற்றுநோய் உடலியல் துறை இல் மாஃபிட் , மாஃபிட் புற்றுநோய் மையம் , புளோரிடா வங்கித் தலை கோலி புற்றுநோய் ஆராய்ச்சி ப்ரோக்ர்யாம் , அமெரிக்கன் புற்றுநோய் சமூகம் , இயற்கை சூழலியல் , புற்றுநோய் உடலியல் துறை ,