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COVID19's cytokine storm ushers in a local complement storm in the lungs


COVID19 s cytokine storm ushers in a local complement storm in the lungs
A new study published in the journal
Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection.
The complement system is an extension of the innate immune system to recognize pathogens and remove them. Prior research has shown a correlation between severe COVID-19 infection and high levels of complement.
The mechanism of action is driving the JAK1/2-dependent local complement hyperactivation. Using the JAK1/2 inhibitor ruxolitinib alone or with remdesivir normalized interferon signature genes inhibited the C3a protein of the complement system created from infected lung cells. ....

Jocelyn Solis Moreira , Jocelyn Solis Moreiraapr , Science Immunology , Corona Virus , Coronavirus Disease Covid 19 , Gene Expression , Immune System , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , அறிவியல் நோயெதிர்ப்பு , கொரோனா வைரஸ் , கீந் வெளிப்பாடு , நோய் எதிர்ப்பு சக்தி அமைப்பு , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,