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Lewy Body Dementia Center Without Walls - Discovery and Translation Labs: Brain Research


Advancing research on a common form of dementia
Mayo Clinic researchers have assembled a team of international experts to investigate key proteins involved in Lewy body dementia.
Lewy Body Dementia Center Without Walls
Investigators from Mayo Clinic s Florida campus are leading a Lewy Body Dementia Center Without Walls research initiative funded by a National Institutes of Health (NIH) specialized center-cooperative agreement grant (U54). The overall goal of the Lewy body dementia multi-institutional Center Without Walls (CWOW) initiative is to deepen the understanding of how the Alzheimer s disease-related protein, amyloid-beta, and the Parkinson s disease-related protein, alpha-synuclein, interact to affect symptom presentation, disease progression and the underlying disease process in Lewy body dementia (LBD). ....

United States , Pamelaj Mclean , Rowena Ross , Tim Bartels , Anthony Wp Fitzpatrick , Dennisw Dickson , National Institutes Of Health , Phd Columbia University , Center Without Walls , Phd University Of Arizona , Lewy Body Dementia Center Without Walls , Phd University College London , Mayo Clinic , National Institutes , Synergistic Interactions , Amyloid Beta Species , Lewy Body Dementia , Columbia University , University College London , ஒன்றுபட்டது மாநிலங்களில் , நேரம் பார்ட்டல்கள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஃப்ட் கொலம்பியா பல்கலைக்கழகம் , மையம் இல்லாமல் சுவர்கள் , ஃப்ட் பல்கலைக்கழகம் கல்லூரி லண்டன் , மயோ சிகிச்சையகம் ,

For α-Synuclein Immunotherapy, Is Going Later the Key?


04 Apr 2021
α-Synuclein immunotherapy is in its infancy, with few trials posting results yet. The first two completed Phase 2s, of Biogen’s cinpanemab and Prothena and Roche’s prasinezumab, were both negative. However, while the cinpanemab study was fully negative, prasinezumab posted positive results on some secondary motor measures. At the 15th International Conference on Alzheimer’s and Parkinson’s Diseases, held virtually March 9–14,
Gennaro Pagano of Roche gave researchers a first look at prespecified subgroup analyses from this study, called PASADENA. It turned out that subgroups of participants whose disease progressed fastest benefited more from prasinezumab, with more slowing of motor decline. Pagano believes this is because the signal-to-noise ratio in these subgroups was greater, allowing the small effect of prasinezumab to be discerned more readily in this slow disease. ....

City Of , United Kingdom , Lundbeck Lu , Tim Bartels , Gennaro Pagano , Madolyn Bowman Rogers , Kirsten Taylor , Werner Poewe , Tiago Outeiro , Innsbruck Medical University , Parkinson Progression Markers Initiative , University Medical Center , International Conference On Alzheimer , University Medical Center Goettingen , International Conference , Progression Markers , Research Institute , University College , Madolyn Bowman , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , நேரம் பார்ட்டல்கள் , ஜெம்நாரோ ப்யாகநொ , கர்ஸ்டந் டெய்லர் , தியகோ ஔஊடேறோ , இந்ந்‌ஸ்ப்ரக் மருத்துவ பல்கலைக்கழகம் ,