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PHILADELPHIA Scientists in the Perelman School of Medicine at the University of Pennsylvania have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder.
This inherited form of DCM which affects at least several thousand people in the United States at any one time and often causes sudden death or progressive heart failure is one of multiple congenital disorders known to be caused by inherited mutations in a gene called
LMNA. The
LMNA gene is active in most cell types, and researchers have not understood why
LMNA mutations affect particular organs such as the heart while sparing most other organs and tissues. ....

University Of Pennsylvania , United States , Pennsylvania Hospital , New Jersey , Qiaohong Wang , Julie Heffler , Benjamin Prosser , Kiran Musunuru , Parisha Shah , Ricardo Linares Saldana , Dilip Thomas , Joseph Wu , Rajan Jain , Andrey Poleshko , Anjali Owens , Kenneth Bedi , Daniel Rader , Deepti Abbey , Joshua Rhoades , Nazish Sayed , Michael Morley , Kenneth Margulies , David Frank , Wenli Yang , Thomas Cappola , Matthew Caporizzo ,