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Researchers from North Carolina State University have found a way to fine-tune the molecular assembly line that creates antibiotics via engineered biosynthesis. ....
by Tracey Peake April 14, 2021 . RALEIGH – Bacteria – such as E. coli – harness biosynthesis to create molecules that are difficult to make artificially. “We already use bacteria to make a number of drugs for us,” says Edward Kalkreuter, former graduate student at NC State and lead author of a paper describing the research. “But we also want to make alterations to these compounds; for example, there’s a lot of drug resistance to erythromycin. Being able to make molecules with similar activity but improved efficacy against resistance is the general goal.” Picture an automobile assembly line: each stop along the line features a robot that chooses a particular piece of the car and adds it to the whole. Now substitute erythromycin for the car, and an acyltransferase (AT) – an enzyme – as the robot at the stations along the assembly line. Each AT “robot” will select a chemical block, or extender unit, to add to the molecule. At each station the A ....
Date Time Researchers Streamline Molecular Assembly Line to Design, Test Drug Compounds Researchers from North Carolina State University have found a way to fine-tune the molecular assembly line that creates antibiotics via engineered biosynthesis. The work could allow scientists to improve existing antibiotics as well as design new drug candidates quickly and efficiently. Bacteria – such as E. coli – harness biosynthesis to create molecules that are difficult to make artificially. “We already use bacteria to make a number of drugs for us,” says Edward Kalkreuter, former graduate student at NC State and lead author of a paper describing the research. “But we also want to make alterations to these compounds; for example, there’s a lot of drug resistance to erythromycin. Being able to make molecules with similar activity but improved efficacy against resistance is the general goal.” ....
Researchers streamline molecular assembly line to design, test drug compounds eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
Directing biosynthesis online Introduction Welcome You are warmly invited to join us online in April 2021. The Directing Biosynthesis conference has been a key meeting in the biosynthetic research calendar for over a decade and is set to be a highlight in 2021 for the community of researchers interested in the biosynthesis of natural products. Organised by the Royal Society of Chemistry, the 2021 conference will host some of the leading researchers from around the world. Networking and discussion are an important part of Directing Biosynthesis meetings and this remains true for the online forum. The conference promises to be a great forum for established and early-career scientists, post-graduate students and industrial researchers to network with each other and build strong collaborations for the future. ....