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Pulmonary endarterectomy improves outcomes in patients with segmental disease A new study, presented today at the AATS 101st Annual Meeting, found that patients treated surgically for segmental Chronic Thromboembolic Pulmonary Hypertension (CTEPH) had excellent outcomes with the vast majority doing very well in the long term without any additional treatment other than surgery. In addition, the study found that the proportion of CTEPH patients with segmental disease increased dramatically during the study period - from 2005 to 2020. At the beginning of the study, roughly seven percent of patients were diagnosed with segmental disease. During the last five years of the study, the proportion rose to an average of 41 percent of patients. ....
Artificial super stool may be a game-changer in the treatment of chronic gut infections The urgent need for human stool donations to treat chronic gut infections could soon be eased with innovative research to develop artificial super stool. The collaborative research aims to create a new generation of microbial therapies that can replace donor-derived faecal microbiota transplantation (FMT). Technology that replicates the complex community of microbes in the human gut will be manufactured in Australia as part of the project. Australian microbiome biotechnology company BiomeBank, in collaboration with RMIT University, has secured $100,000 in funding from the Innovative Manufacturing Cooperative Research Centre (IMCRC) to develop the new bioreactor technology. ....
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Chronic SARS-CoV-2 infections favor viral adaptation, says study The rollout of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), agent behind the notorious and catastrophic coronavirus disease 2019 (COVID-19) pandemic, was expected to help usher in the end of the extreme social and economic devastation associated with containment measures. A new study, released as a preprint on the medRxiv server, offers a look at how to keep these hopes alive in the current context of highly infectious variants, which often display immune escape mutations. Natural selection and VOCs The emergence of recent mutant strains, called variants of concern (VOCs), in the UK, South Africa and Brazil, has shattered expectations of a speedy end to the pandemic. Prominent vaccine makers are now stressing the need for repeated boosters after a year of the original course, or less, along with updated vaccines to overcome the loss of efficacy against the n ....