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Frontiers | Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer Model

1
1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States
2Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, United States
3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States
4Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, United States
Tumor-stromal interactions within the tumor microenvironment (TME) influence lung cancer progression and response to therapeutic interventions, yet traditional
in vitro studies fail to replicate the complexity of these interactions. Herein, we developed three-dimensional (3D) lung tumor models that mimic the human TME and demonstrate tumor-stromal crosstalk mediated by extracellular vesicles (EVs). EVs released by tumor cells, independent of p53 status, and fibroblasts w ....

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Kanser dünyada en öldürücü hastalıklar arasında ilk sıralarda yer alm

Kanser dünyada en öldürücü hastalıklar arasında ilk sıralarda yer alm
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En qué consiste el Plan Nacional de Vacunación contra la COVID-19

En qué consiste el Plan Nacional de Vacunación contra la COVID-19
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Reporte oficial del Covid 19 al 8 de enero del 2021 en la región San Martín

Reporte oficial del Covid 19 al 8 de enero del 2021 en la región San Martín
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When Recurring Respiratory Symptoms Could be the Sign of a Chronic Lung Condition

When Recurring Respiratory Symptoms Could be the Sign of a Chronic Lung Condition
Dec. 21, 2020
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(BPT) - Living with a chronic lung condition can be challenging. The first step toward improving your lung health is understanding what kind of lung condition you have and what you can do to manage your condition in close partnership with your doctor.
One such condition,
Mycobacterium avium complex (MAC) lung disease, can be serious and can worsen over time. Commonly found in the environment, MAC bacteria is the most common species that causes nontuberculous mycobacterial (NTM) lung disease. MAC bacteria can get inside your lungs when you breathe them in through daily activities, such as showering or gardening. While most people who come in contact with MAC do not develop an infection, people at risk are those with other lung conditions such as ....

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