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Eight hallmarks of environmental exposures that contribute to disease

Eight hallmarks of environmental exposures that contribute to disease
A new review of existing evidence proposes eight hallmarks of environmental exposures that chart the biological pathways through which pollutants contribute to disease: oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function.
The study by researchers at Columbia University Mailman School of Public Health, Ludwig Maximilian University, and Hasselt University is published in the journal
Cell.
Every day we learn more about how exposure to pollutants in air, water, soil, and food is harmful to human health. Less understood, however, are the specific biological pathways through which these chemicals inflict damage on our bodies. In this paper, we provide a framework to understand why complex mixtures of environ ....

Andrea Baccarelli , Emily Henderson , Environmental Health Sciences At Columbia Mailman School , Columbia University Mailman School Of Public Health , Ludwig Maximilian University , Hasselt University , Columbia University Mailman School , Public Health , Environmental Health Sciences , Columbia Mailman , Air Pollution , Nervous System , Oxidative Stress , எமிலி ஹென்டர்சன் , சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் இல் கொலம்பியா மெயில்மேன் பள்ளி , கொலம்பியா பல்கலைக்கழகம் மெயில்மேன் பள்ளி ஆஃப் பொது ஆரோக்கியம் , லுட்விக் மாக்ஸிமிலியன் பல்கலைக்கழகம் , கொலம்பியா பல்கலைக்கழகம் மெயில்மேன் பள்ளி , பொது ஆரோக்கியம் , சுற்றுச்சூழல் ஆரோக்கியம் அறிவியல் , கொலம்பியா மெயில்மேன் , அேக பொல்யூஶந் , பதட்டமாக அமைப்பு , மன அழுத்தம் ,

Molecular imaging can predict response to novel metastatic breast cancer treatment

Molecular imaging can predict response to novel metastatic breast cancer treatment
Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients who are resistant to hormonal therapy. According to research published in the February issue of the
Journal of Nuclear Medicine, positron emission tomography (PET) imaging using an imaging agent called 18F-fluoroestradiol can help to determine which patients could benefit from treatments that could spare them from unnecessary chemotherapy.
Nearly two-thirds of invasive breast cancers are ER-positive, and endocrine therapy is the mainstay of treatment for these tumors because of its favorable toxicity profile and efficacy. Should cancer progress in these patients, however, salvage endocrine therapy with molecularly targeted agents or chemotherapy can help. ....

United States , Hannahm Linden , Emily Henderson , Journal Of Nuclear Medicine , Seattle Cancer Care Alliance In , Nuclear Medicine , Athena Distinguished Professor , Breast Medical Oncologist , Washington Fred Hutchison Cancer Research Center , Seattle Cancer Care Alliance , Breast Cancer , Molecular Imaging , Aromatase Inhibitor , Ductal Carcinoma , Hormonal Therapy , Invasive Ductal Carcinoma , Positron Emission Tomography , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , இதழ் ஆஃப் அணு மருந்து , சீட்டில் புற்றுநோய் பராமரிப்பு கூட்டணி இல் , அணு மருந்து , அதீனா புகழ்பெற்ற ப்ரொஃபெஸர் , மார்பக மருத்துவ புற்றுநோயியல் நிபுணர் , வாஷிங்டன் ஃப்ரெட் ஹட்ச்சன் புற்றுநோய் ஆராய்ச்சி மையம் , சீட்டில் புற்றுநோய் பராமரிப்பு கூட்டணி ,

Vitamin D deficiency associated with higher risk of COVID-19 hospitalization

Vitamin D deficiency associated with higher risk of COVID-19 hospitalization
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, continues to spread worldwide.
In an enormous research effort, the global scientific community continues to try and identify the causes of a wide variation in disease manifestations and severity.
A new study published in the journal
Endocrinein January 2021 shows that low levels of vitamin D are associated with a higher risk of COVID-19 hospitalization.
Risk factors for severe COVID-19
Of the 97 million confirmed cases across the globe, over 2 million people have died. The unusual nature of this virus is that it causes severe or even critical illness in a significant minority of patients, while the vast majority escape with no, mild or moderate symptoms. ....

Liji Thomas , Kavun Halyna Shutterstock , Endocrinein January , Kavun Halyna , Coronavirus Disease Covid 19 , Sars Cov 2 , Vitamin D , Vitamind Deficiency , Corona Virus , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , வைட்டமின் ட , கொரோனா வைரஸ் , நீரிழிவு நோய் , நோய் எதிர்ப்பு சக்தி பதில் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study finds new evidence about the positive role of androgens in breast cancer treatment

Study finds new evidence about the positive role of androgens in breast cancer treatment
Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.
Published today in
Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the role of androgens - commonly thought of as male sex hormones but also found at lower levels in women - as a potential treatment for estrogen receptor positive breast cancer.
Watch a video explainer about the new study at - https:/ ....

University Of Adelaide , South Australia , Chloe Marshall , Stephen Birrell , Theresa Hickey , Dwayne Tilley , Emily Henderson , Dame Roma Mitchell Cancer Research Laboratories , Garvan Institute , Garvan Institute Of Medical Research , Head Of The Breast Cancer Group , Veru Inc , Nature Medicine , Medical Research , Associate Professor Theresa Hickey , Breast Cancer Group , Associate Professor , Professor Elgene Lim , Connie Johnson Breast Cancer Research Lab , Breast Cancer , Cancer Treatment , தெற்கு ஆஸ்திரேலியா , சோலி மார்ஷல் , ஸ்டீபன் பிர்ரெல் , தெரேசா ஹிக்கி , வேன் டில்லி ,

Welcome To IANS Live - LatestNews - Male sex hormones may help treat breast cancer: Study

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life. Abno ....

New South Wales , India Private , News Service , All Rights , புதியது தெற்கு வேல்ஸ் , இந்தியா ப்ரைவேட் , செய்தி சேவை , அனைத்தும் உரிமைகள் ,