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8 teams advance in RTI International's $5M Forethought challenge

8 teams advance in RTI International's $5M Forethought challenge
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Opinion | In the Race for a Covid-19 Pill, a Little Lab Plays a Big Role

Mr. Adams is a journalist in Atlanta who has written about the pharmaceutical industry.
ATLANTA Nine years ago, Dr. Dennis Liotta, a professor of organic chemistry at Emory University, set out to change the way drugs are developed for so-called neglected diseases those that primarily affect populations in poorer countries and for which there exist few, if any, safe and effective treatments.
“The cold hard truth is that it can cost billions of dollars and take decades to develop a new drug,” he said during a TEDx talk in 2016, shortly after the World Health Organization had declared the Zika virus a neglected disease that had long been overlooked in the African countries where it is endemic an international public health emergency. “So pharmaceutical companies almost invariably only pursue drugs for diseases that will generate large profits.” ....

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The Covid pill: new antiviral taskforce faces tough challenge

The candidates that have been considered include remdesivir, originally developed to treat hepatitis C and Ebola. But Nature says that “some clinical studies have failed to confirm that it offers [Covid] patients any benefit. And the drug is expensive, difficult to manufacture and must be given intravenously in a hospital - all undesirable attributes in the middle of a pandemic.”
Experts are hoping that some of those issues might be avoided with another antiviral drug, molnupiravir, which is undergoing late-stage clinical testing as a Covid treatment by the US National Institutes of Health (NIH). Meanwhile, the NHS is testing an antiviral called favipiravir in trials involving UK patients. ....

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